2型糖尿病血浆纤维蛋白原、血小板参数及高敏CRP与微血管病变的关系

目的探讨2型糖尿病血浆纤维蛋白原、血小板参数及高敏CRP与微血管病变的关系。方法将243例糖尿病患者分为A组(有微血管病变组123例)、B组(无微血管病变组120例);120例健康人为正常对照组。分别检测血浆纤维蛋白原(Fib)、血小板计数(PLT)、血小板压积(PCT)、血小板平均体积(MPV)和血小板体积分布宽度(PDW)、高敏CRP(hs-CRP)的水平。结果与正常对照组比,A组PCT、MPV、PDW、Fib、Hs-CRP的检测差异有统计学意义(P<0.01),PLT检测有差异有统计学意义(P<0.05)。B组Fib、Hs-CRP的检测差异有统计学意义(P<0.01),PLT检测差异有统计学意义(P<0.05)。A组与B组相比PCT检测差异有统计学意义(P<0.01),MPV、PDW、Fib、Hs-CRP检测差异有统计学意义(P<0.05)。结论 PCT、MPV、PDW、Hs-CRP、Fib的检测对糖尿病微血管病变的早期诊断有重要的临床意义。

The relationship between fibrinogen,platelet parameters,hs-CRP and microvascular complication of patients with type 2 diabetes

Objective Eveluated the relationships microvascular complication of fibrinogen,platelet parameters,and hs-CRP in patients with type 2 diabetes.Methods 243 patients with type 2 diabetes were divided into group A(123 type 2 diabetes patients with microvascular complication) and group B(120 type 2 diabetes patients without microvascular complication).And the normal cintrol group contained 120 health people.Determined the level of the the fibrinogen,PLT,PCT,MPV,PDW,hs-CRP in blood samples of research subjects respectively.Results The level of PCT,MPV,PDW,Fib and hs-CRP in group A were significantly higher than that in control group(P<0.01),as well as PLT(P<0.05).The level of PCT,MPV,PDW,fibrinogen and hs-CRP in group B were significantly higher than that in control group(P<0.01),as well as PLT(P<0.05).The level of MPV,PDW,fibrinogen and Hs-CRP in group A were significantly different with group B(P<0.05),as well as PCT(P<0.01).Conclusion It were demonstrated that the determination of fibrinogen,PLT,PCT,MPV,PDW and hs-CRP were of important clinical significance in the early diagnosis of diabetic microvascular complication.