| 纤溶和凝血功能变化与2型糖尿病微血管病变的关系 |
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| 引用本文： | 王少波,施秉银,王养维,吴贵福.纤溶和凝血功能变化与2型糖尿病微血管病变的关系[J].临床医学,2006,26(7):15-16. |
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| 作者姓名： | 王少波 施秉银 王养维 吴贵福 |
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| 作者单位： | 1. 陕西省人民医院内分泌科,西安,710068
2. 西安交通大学第一医院内分泌科 |
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| 摘 要： | 目的探讨凝血与纤溶功能变化在糖尿病微血管病变中的临床意义。方法纤溶酶原激活物抑制物-1（PAI-1）活性采用发色底物法，纤维蛋白原（Fg）采用免疫浊度法测定。结果糖尿病无微血管病变组血浆PAI-1和Fg水平高于小常对照组（P〈0．05），糖尿病微血管病变组血浆PAI-1和Fg水平明显高于无微血管病变组及正常对照组（P〈0．01）。结论2型糖尿病患者存在血液的高凝及低纤溶状态，在发生2型糖尿病微血管病变后更为明显，检测2型糖尿病患者血浆中PAI-1和Fg水平，对糖尿病微血管病变的预防和治疗具有一定的临床意义。
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| 关 键 词： | 糖尿病微血管病 纤溶酶原激活物抑制物-1 纤维蛋白原 |
| 收稿时间： | 2005-12-29 |
| 修稿时间： | 2005-12-29 |
The relationship between changes of plasma fibrinolysis and coagulation parameters and type 2 diabetic microangiopathy |
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| WANG Shaobo,SHI Bingyin,WANG Yangwei,WU Guifu.The relationship between changes of plasma fibrinolysis and coagulation parameters and type 2 diabetic microangiopathy[J].Clinical Medicine,2006,26(7):15-16. |
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| Authors: | WANG Shaobo SHI Bingyin WANG Yangwei WU Guifu |
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| Institution: | WANG) Shaobo~ |
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| Abstract: | Objective To investigate the changes of plasma coagulation and fibrinolysis parameters in type 2 diabetic microangiopathy.Methods The plasminogen activator inhibitor-1(PAI-1) and plasma fibrinogen(Fg) in type 2 diabetes were measured.Results The levels of PAI-1 and Fg were signifiantly increased in both groups of patients with microangiopathy and without microangiopathy compared with controls(P<0.05).In diabetic group,it was signifiantly higher in patients with microangiopathy than those without diabetic microangiopathy(P<0.01).Conclusion The condition of high coagulation and low fibrinolytic base was in type 2 diabetes mellitus,and even more in diabetic microangiopathy.It's key to measure the levels of(PAI-1) and Fg for prevention and treatment in type 2 diabetic microangiopathy. |
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| Keywords: | Diabetic microangiopathy Plasminogen activator inhibitor - 1 Plasma fibrinogen |
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