光学相干断层成像术测定国人视网膜神经纤维层厚度正常值的初步研究

目的:光学相干断层成像术(optical coherence tomograpy,OCT)测定国人视网膜神经纤维层(reti-nal nerve fiber layer,RNFL)厚度的正常值,为在青光眼早期诊断中的应用奠定基础。方法:使用OCT对77例111只正常眼进行环绕视乳头的RNFL扫描(3.46mm直径),分析不同年龄、性别、眼别RNFL厚度的差异。结果:不同性别、眼别间RNFL的相应厚度无显著差异(P>0.05);各年龄组RNFL厚度平均值(x±s,μm):上象限为128.00±10.31～149.00±13.17、下象限132.95±9.54～142.33±10.60、全周平均RNFL109.00±4.72～114.28±7.98;RNFL随年龄增长有变薄的趋势,以上象限为明显(P<0.05)。结论:OCT检测所得RNFL厚度的均值与性别及眼别无关;应以年龄分组,在本研究的基础上扩大检验的样本数,建立RNFL正常值。眼科学报1998;14:207～209。

A Quantitative Measurement of Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography in Normal Chinese People

PURPOSE: To measure retinal nerve fiber layer(RNFL) thickness in normal Chinese people for the use of early diagnosis in glaucomatous patients. METHODS: Optical Coherence Tomography(OCT) was used in 111 eyes of 77 Subjects to create cylindrical cross sections of the RNFL around the optic nerve head with scan diameter of 3.46 mm. The differences in RNFL thickness were analyzed with age, sex, either eye. RESULTS: We found a decrease in RNFL thickness with aging especially in the superior quadrant(P < 0.05), but there weren't significant difference between right and left eyes, neither the sex(P > 0.05). The Mean RNFL thickness of different ages(mean +/- s) was as following: the superior quadrant 128.00 +/- 10.31-149.00 +/- 13.17, the inferior quadrant 132.95 +/- 9.54-142.33 +/- 10.60, the overall mean RNFL thickness 109.00 +/- 4.72-114.28 +/- 7.98 microns. CONCLUSION: The preliminary study showed that neither sex nor either eye were associated with significant differences in RNFL thickness. It is necessary to define the normative value by age group on a larger scale.