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Enhancement of norepinephrine-induced transient contraction in aortic smooth muscle of diabetic mice
Authors:Abe Asaki  Kawasoe Chiaki  Kondo Yasuhiro  Sato Katsunori
Affiliation:Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700 8530, Japan. abeasaki@cc.okayama-u.ac.jp
Abstract:Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.
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