生物型硬脑膜原位植入转归的实验研究

目的通过动物实验,观察新型生物型人工硬脑膜原位植入后的转归过程和演变趋势。方法杂种犬12只分为4组,每组各3只。用冠昊公司生物型人工硬脑膜实施外科手术替换动物的原位硬脑膜,主要观察替换后3、6、9、12个月不同时期的新生硬脑膜组织形成及演变过程。结果生物型人工硬脑膜按预期的设计思路显示了植入后的中远期转归过程,植入物内可见自体新生纤维组织逐步建立,形成由原植入物纤维结缔组织和新生活体组织的纤维组织交织在一起的“过渡态结构”。呈现新生组织逐步增加,最终替代残留植入物的趋势。经历1 年的缓慢降解,植入材料的残留部分仍然保持了比较完整的微观形态,并与周围新生组织的纤维组织交织在一起, 使“过渡态结构”在整个转归过程中始终能保持其基本的机械性能。结论新型生物型人工硬脑膜可望成为一种理想的硬膜修补材料。

Evolution of a biological dural graft in a canine model

Objective By means of a canine model, to observe the evolution of the prosthetic dural graft in different implanting periods, and further confirm the design intent of the AVH material. Methods 12 mongrel dogs were divided into 4 groups (3 in each group). For each animal, a portion of the animal dural mater was replaced by implanting an AVH graft. The animals in each group were sacrificed at 3, 6, 9, 12 months after implantation, respectively, to evaluate the evolution process of the surgically replaced portion by means of gross exam as well as histology analysis. Results The AVH graft indicated that regenerated host dura-like collagen fiber had gradually encroached the implant and the defected portion became a "composite" biomaterial with both original implanting tissue and host living tissue. After a year of remodeling the remaining AVH material, although reverse substituted half way through, was still kept its microscopic structure, so that the combined tissue sheet was able to remain an ideal mechanical property through substitute the original implant completely. To investigate the final evolution result further studies are needed with larger animal populations as well as longer observation durations. Conclusions The AVH graft may be a more practical material for the dural replacement in the neural surgical procedures.