川芎嗪注射液对早发型重度子痫前期患者妊娠结局的影响

目的探求川芎嗪注射液对早发型重度子痫前期患者妊娠结局的影响。方法回顾性分析河北省儿童医院2016年12月至2018年12月诊治的早发型重度子痫前期患者99例临床资料,按治疗方式不同分为两组。两组均接受常规对症治疗,对照组48例采用硫酸镁治疗,试验组51例在对照组治疗基础上采用川芎嗪注射液治疗,比较两组血管内皮功能、脐动脉S/D值、凝血功能指标、视网膜病变、妊娠结局及安全性。结果治疗后,两组可溶性血管内皮生长因子受体-1(sFlt-1)、脐动脉S/D值低于治疗前,血管内皮生长因子(VEGF)高于治疗前,且试验组优于对照组,差异具有统计学意义(P<0.05);试验组凝血酶原时间(PT)、凝血酶时间(TT)、血小板计数(PLT)水平均高于治疗前,D-二聚体(D-D)水平低于治疗前,且优于对照组,差异具有统计学意义(P<0.05);治疗后,试验组视网膜病变分级优于对照组,差异具有统计学意义(P<0.05);试验组新生儿体重、终止妊娠孕周较对照组高,失血量较对照组低,差异具有统计学意义(P<0.05);试验组患者胎儿窘迫、胎盘早剥、新生儿黄疸、新生儿入住NICU、新生儿窒息发生率均低于对照组,差异具有统计学意义(P<0.05)。结论早发型重度子痫前期患者采用川芎嗪注射液治疗可改善凝血功能指标,提升血管内皮功能,改善视网膜病变及妊娠结局,且用药安全性高。

Effect of ligustrazine injection on the pregnancy outcome of patients with early-onset severe preeclampsia

Objective To explore the effect of ligustrazine injection on the pregnancy outcome of patients with early-onset severe preeclampsia.Methods The clinical data of 99 cases with early-onset severe preeclampsia admitted to our hospital from December 2016 to December 2018 were retrospectively analyzed.They were divided into two groups according to the different treatment methods.Both groups received routine symptomatic treatment.The 48 patients in the control group were treated with magnesium sulfate,whereas the 51 cases in the experimental group were treated with ligustrazine injection combined with magnesium sulfate.The vascular endothelial function,umbilical artery S/D value and coagulation function,retinopathy,pregnancy outcomes,and safety were compared between the two groups.Results After treatment,the levels of soluble vascular endothelial growth factor receptor-1(sFlt-1)and umbilical artery S/D in both groups were shown to be lower than those before treatment,and the level of vascular endothelial growth factor(VEGF)was higher than that before treatment,with the indicators in the experimental group better than those in the control group,all with statistically significant differences(P<0.05).The prothrombin time(PT),thrombin time(TT),and platelet count(PLT)levels in the experimental group were higher than those before treatment,and the level of D-dimer(DD)was lower than that before treatment,with the levels in the experimental group better than those in the control group,with statistically significant differences(P<0.05).After treatment,the grade of retinopathy in the experimental group was better than that in the control group,with statistically significant difference(P<0.05).In the experimental group,the weight of newborns was heavier,the gestational weeks of termination were larger and the blood loss was less than those in the control group accordingly,all with statistically significant differences(P<0.05).The incidences of fetal distress,placental abruption,neonatal jaundice,neonatal stay NICU,neonatal asphyxia were lower than those in the control group,with statistically significant differences(P<0.05).Conclusions For treatment of patients with early-onset severe preeclampsia,ligustrazine injection can improve the blood coagulation function,vascular endothelial function and the retinopathy and pregnancy outcome,with higher safety.