电灼结合中药内服外洗治疗尖锐湿疣的疗效观察

目的观察电灼结合中药内服外洗治疗尖锐湿疣的临床疗效及对患者T淋巴细胞亚群的影响。方法选择从2013年7月至2017年11月山西医科大学附属大同市第三人民医院泌尿外科治疗尖锐湿疣的患者148例,随机分成对照组和观察组两组,每组74例。对照组患者单独采用电灼治疗;观察组患者在采用电灼基础上结合中药内服外洗共同治疗。结果观察组尖锐湿疣患者复发率为10.8%,低于对照组尖锐湿疣患者复发率28.4%,差异具有统计学意义。(P<0.01)。两组治疗后复发组CD3+细胞、CD4+细胞水平、CD4+/CD8+细胞比值较未复发组低,而CD8+细胞水平较未复发组高,差异具有统计学意义。(P<0.05)。治疗后,观察组尖锐湿疣患者CD3+水平、CD4+水平、CD4+/CD8+比值高于对照组尖锐湿疣患者,且观察组尖锐湿疣患者CD8+水平低于对照组尖锐湿疣患者CD8+水平,差异具有统计学意义(P<0.01)。结论电灼结合中药内服外洗能减少尖锐湿疣的复发率。在临床治疗中,监测尖锐湿疣患者外周血T淋巴细胞亚群,对尖锐湿疣患者治疗后的复发预估及相应增强免疫治疗具有重要的指导意义。

Curative effect of electrocautery combined with traditional Chinese medicine in the treatment of condyloma acuminatum

Objective To investigate the treatment effect of electrocautery combined with traditional Chinese medicine in the treatment of condyloma acuminatum(CA) and its effect on the patients′T-lymphocyte subsets. Methods 148 CA patients in the Third People′s Hospital of Datong between July 2013 and November 2017 were selected and randomly divided into control group and observation group, with 74 cases in each group. Patients in the control group were given electrocautery treatment only, whereas those in the observation group were treated with electrocautery combined with traditional Chinese medicine treatment. Results The recurrence rate in the observation group(10.8%) was lower than that in the control group(28.4%), with statistically significant differences(P<0.01). After treatment, the levels of CD3+ cells, CD4+ cells andCD4+/CD8+ ratio in the recurred group were lower while the CD8+ cells were higher than those in the non-recurred group, with statistically significant differences(P<0.05). After treatment, the levels of CD3+ cells, CD4+ cells andCD4+/CD8+ ratio in the observation group were higher while the CD8+ cells were lower than those in the control group, with statistically significant differences(P<0.01). Conclusions Electrocautery combined with traditional Chinese medicine treatment can reduce the recurrence rate of CA. In clinical treatment, the detection of T-lymphocyte subsets in peripheral blood will play an important instruction role in the evaluation of recurrence and the corresponding enhanced immunotherapy of patients with CA.