拉贝洛尔联合脉络宁注射液对妊娠高血压综合征患者血清ET、IGF-1水平和妊娠结局的影响

目的探讨拉贝洛尔联合脉络宁注射液对妊娠高血压综合征(pregnancy induced hypertension syndrome,PIH)患者血清内皮素(ET)、胰岛素样生长因子-1(IGF-1)水平和妊娠结局的影响。方法选取2016年12月至2018年2月丽水市中心医院诊治的108例PIH患者作为研究对象。采用随机数字表法将其分为观察组和对照组,每组54例患者。在给予常规干预治疗的基础上,观察组给予拉贝洛尔联合脉络宁注射液治疗,对照组患者给予拉贝洛尔治疗。比较两组患者的临床疗效和母婴结局,以及治疗前后患者血压和血清ET、IGF-1水平变化情况。结果治疗后,观察组患者临床总有效率(96.3%)高于对照组患者(74.1%),其差异具有统计学意义(P<0.05);观察组患者剖宫产率和早产发生率均显著低于对照组患者,其差异均具有统计学意义(均P<0.05);观察组新生儿5min Apgar评分显著高于对照组新生儿,其差异具有统计学意义(P<0.05)。治疗后,两组患者舒张压(DBP)和收缩压(SBP)均有显著降低,且观察组低于对照组,其差异均具有统计学意义(均P<0.05)。治疗后,两组患者血清ET均有明显降低,IGF-1均有明显升高,且观察组血清ET低于对照组、IGF-1水平高于对照组,其差异均具有统计学意义(均P<0.05)。两组患者治疗不良反应发生率比较,其差异均无统计学意义(均P>0.05)。结论常规治疗基础上,采用脉络宁注射液配合拉贝洛尔联合治疗妊娠高血压综合征效果显著,能够有效控制患者血压水平,降低血清ET水平,升高IGF-1水平,降低母婴不良妊娠结局发生率,且安全性较好。

Effects of labetalol and Mailuoning injection on the pregnancy outcome,serum ET and IGF-1 levels in patients with pregnancy-induced hypertension

Objective To investigate the effects of labetalol combined with Mailuoning injection on the pregnancy outcome,serum endothelin(ET)and insulin-like growth factor-1(IGF-1)levels in patients with pregnancy-induced hypertension(PIH).Methods 108 PIH patients in Lishui Central Hospital from December 2016 to February 2018 were selected and divided into observation group(54 cases)and control group(54 cases).The patients in the control group were treated with labetalol,while those in the observation group were treated with labetalol and Mailuoning injection.The clinical efficacy,maternal and infant outcomes,blood pressure,serum ET and IGF-1 levels were compared between the two groups.Results The total clinical effective rate in the observation group(96.3%)was significantly higher than that in the control group(74.1%),with statistically significant differences(P<0.05).The cesarean section rate and premature delivery rate in the observation group were significantly lower than those in the control group,with statistically significant differences(all P<0.05).The Apgar score in the observation group was significantly higher than that in the control group,with statistically significant differences(P<0.05).The diastolic blood pressure(DBP)and systolic blood pressure(SBP)in the two groups after treatment were significantly decreased compared with those before treatment,and those in the observation group were lower(all P<0.05).After treatment,the level of serum ET in the observation group was lower than that in the control group,and the IGF-1 was higher than that in the control group(all P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(all P>0.05).Conclusions Mailuoning injection combined with labetalol is of remarkable effect on PIH.It can significantly reduce blood pressure,serum ET level and increase the level of IGF-1,which can significantly reduce the incidence of adverse maternal and infant outcomes with high safety.