不育男性合并UU感染者抗精子抗体及不同类型分布

目的分析不育男性合并解脲脲原体(UU)感染者抗精子抗体及不同类型分布。方法选取2017年1月至2019年1月文昌市人民医院诊治的331例男性不育患者作为研究对象。使用全自动精子分析仪检测患者精子参数,同时检测患者UU感染率、抗精子抗体(AsAb)及其不同类型分布状况。结果 331例患者UU感染人数为176例,阳性率为53.17%;将331例患者依据UU感染情况分为2组,分别为UU阳性组和UU阴性组,UU阳性组患者向前运动精子比例、精液量、活动精子浓度与精子总数均低于UU阴性组,差异有统计学意义(P<0.05);UU阳性组患者其精浆AsAb阳性率为41.48%(73/176),UU阴性组患者其精浆AsAb阳性率为38.06%(59/155),差异无统计学意义(P>0.05);UU阳性组患者血清AsAb-IgA阳性率高于UU阴性组,差异有统计学意义(P<0.05)。结论临床不育男性UU感染患者其精子质量下降,这可能和患者血清内AsAb-IgA阳性率上升有关。

Antisperm antibodies and different types of distribution in infertile men with UU infection

Objective To analyze the anti-sperm antibodies(AsAb) and different types of distribution in infertile men with Ureaplasma urealyticum(UU) infection. Methods A total of 331 male infertility patients treated at Wenchang People′s Hospital from January 2017 to January 2019 were selected as the research subjects. The sperm parameters of the patients were detected by the automatic sperm analyzer, and the UU infection rate, AsAb, and their different types of distribution were also detected at the same time. Results There were 176 patients with UU infections, a positive rate of 53.17%. The 331 patients were divided into UU-positive group and UU-negative group. The proportion of sperm forward motility, semen volume, active sperm concentration, and total sperm count in the UU-positive group were all lower than those in the UU-negative group, with statistically significant differences(P<0.05). The positive plasma AsAb rate of the UU-positive group and UU-negative group was 41.48%(73/176) and 38.06%(59/155) accordingly, without statistically significant differences(P>0.05). The positive rate of serum AsAb-IgA in the UU-positive group was higher than that in the UU-negative group, with statistically significant difference(P<0.05). Conclusions The sperm quality of infertile men with UU infection decreases, which may be related to the increase of serum AsAb-IgA positive rate.