胰岛素抵抗高血压大鼠血清瘦素水平与胰岛素抵抗的关系

目的:探讨胰岛素抵抗高血压大鼠血清瘦素水平与胰岛素抵抗的关系。方法:以高果糖饲料喂养雄性SD大鼠复制胰岛素抵抗高血压大鼠模型,测定其收缩压(SBP)、空腹皿糖(FBG)、空腹血清胰岛素(FINS)和瘦素(LP)水平,用稳态模型(HOMA)评估胰岛素抵抗(IR),分析血清瘦素水平与胰岛素抵抗的相关性及与血压等其他指标的关系。结果:与对照组相比,模型鼠组SBP、FINS、HOMA-IR明显升高(P<0.01,P<0.01,P<0.05),FBG无明显变化(P>0.05);LP显著升高(P<0.05);模型鼠组的LP与FINS、SBP、HOMA-IR呈显著正相关(P<0.05)。结论:高果糖饲料喂养SD大鼠能形成胰岛素抵抗及高血压,并有高瘦素血症。瘦素与胰岛素抵抗的形成关系密切。

Relationship of serum leptin level and insulin resistance in hypertensive rats with insulin resistant

Objective: To investigate the relationship of serum leptin level with insulin resistance in rats fed with high fructose diet. Methods: Male Spraque-Darley rats were fed with high fructose diet to establish insulin resistant hypertensive rat model. The concentration of serum glucose, insulin and leptin were determined. The HOMA model was used to evaluate insulin resistance (IR). Results: SBP , insulin level and HOMA-IR in rats of model group were significant higher than those in normal control group, following hyperleptinemia (P<0. 05 or P<0. 01). In rats of model group, leptin was positively related to SBP, insulin and HOMA-IR (P<0. 05 all). Conclusion: High fructose diet can induce insulin resistance, hypertension and hyperleptinemia in SD rats. Leptin may be associated with the mechanism leading to insulin resistance.