紫杉醇联合顺铂及5-氟尿嘧啶治疗进展期胃癌的临床观察

目的：观察紫杉醇（PTX）联合顺铂（CDDP）及5-氟尿嘧啶（5-Fu）方案（PCF方案）治疗进展期胃癌的近期疗效及不良反应.方法：选取病理检查证实的晚期胃癌患者36例,所有患者均有可评价病灶.化疗方案为：PTX 175mg/m2 ivgtt d1;CDDP 20mg/m 2,ivgtt d1-5;5-FU 750mg/m2,ivgtt24h d1-5.28天为1周期,所有患者至少接受2周期化疗.结果：36例患者均完成2个周期以上化疗,总有效率为61.1%,其中完全缓解（CR）3例,部分缓解（PR）19例,疾病稳定（NC）8例,疾病进展（PD）6例.生存期为5个月-24个月,中位生存期为11.5个月.主要不良反应为恶心、呕吐、腹泻和血白细胞、血红蛋白及血小板减少,其中Ⅲ度-Ⅳ度白细胞减少9人（25.0%）,其余大部分反应为Ⅰ度-Ⅱ度,无化疗相关死亡病例.结论：紫杉醇联合顺铂、5-氟尿嘧啶化疗方案治疗进展期胃癌疗效较好,不良反应可耐受.

Clinical observation of paclitaxel plus cisplatin and 5-fluorouracil in the treatment of advanced gastric cancer

Objective：To observe the recent efficacy and toxicity of combination chemotherapy with paclitaxel plus cisplatin and 5 -fluorouracil （PCF）in the treatment of advanced gastric cancer. Methods ：Thirty -six measurable patients pathologically were enrolled into this study. The chemotherapy regimen was comprised of paclitaxel 175mg/m2, iv gtt d1 ; CDDP 20mg/m2 ,ivgtt d1-5 ;5 - Fu 750mg/m2 ,ivgtt24h d1-5- The regimen was given per 28 days. All enrolled patients received at least two cycles of treatment. Results：Thirty - six patients received at least two cycles of treatment. Response rate was 61.1% ,including complete response 3 cases, partial response 19 cases, stable disease 8 cases, and progressive disease 6 cases. Survival time was 5 months - 24 months, and with a median survival of 11.5 months. Main side effects were nausea, vomiting, diarrhea, white blood cells, hemoglobin and thrombocytopenia, grade Ill -1V leueopenia 9 cases（25.0% ）,most of the remaining reactions of grade were I - ll degrees,and no chemo- therapy related deaths. Conclusion： The combination of paclitaxel plus cisplatin and 5 - fluorouracil is an cffective chemotherapy in the treatment of advanced gastric cancer, and toxicity can be tolerated.