注射用头孢噻酚钠与3种输液的配伍稳定性

摘要目的考察注射用头孢噻酚钠与果糖注射液、转化糖电解质注射液和木糖醇注射液配伍的稳定性。方法模拟临床用药浓度，在室温（20±1）℃下放置6 h，观察配伍液外观、pH变化，并用高效液相色谱法测定配伍液中头孢噻酚的含量变化。结果头孢噻酚钠与木糖醇注射液的配伍液0～6 h内含量、外观均无显著变化，6 h时pH下降0.5；头孢噻酚钠与转化糖电解质注射液的配伍液0～6 h内pH、外观、含量均无明显变化；头孢噻酚钠与果糖注射液的配伍液，0～6 h内pH、外观均无明显变化，2 h含量＞98%，6 h含量下降至95.71%。结论在实验条件下，3种输液与头孢噻酚钠配伍基本稳定，可以作为头孢噻酚钠的溶媒，头孢噻酚钠与果糖注射液配伍时宜在2 h内完成输注。

Study on Compatible Stability of Cefalotin Sodium for Injection in Three Kinds of Infusions

Objective To study the compatibility stability of cefalotin sodium after mixing with fructose injection,invert sugar electrolyte injection and xylital injection.Methods The pH value and appearance were observed after cefalotin sodium mixing with 3 kinds of injections for 6 hours at(20±1) ℃,and the content of cefalotin sodium was determined by high performance liquid chromatography(HPLC).Results Appearance and the content of cefalotin sodium in xylital injection had no significant change within 6 hours,but the pH value decreased 0.5;appearance,the pH value and the content of cefalotin sodium in invert sugar electrolyte injection had no significant change within 6 hours;appearance and the pH value of cefalotin sodium in fructose injection had no significant change within 6 hours,but the content decreased.Conclusion Cefalotin sodium mixed with the three kinds of injections at(20±1)℃ is stable.Cefalotin sodium mixed with fructose injection should be used within 2 hours.