门静脉插管化疗预防大肠癌肝转移的疗效观察

目的 探讨5-FU门静脉插管化疗在预防DukesB、C期大肠癌肝转移中的作用。方法：随机双盲对照的DukesB、C期大肠癌患80例，其中根治性切除加门静脉化疗(治疗组)40例，单纯根治性切除术(对照组)40例，每年进行随访。结果 治疗组3年肝转移发生率8．5％，明显低于对照组30．8％；治疗组术后1年、3年、5年生存率分别为97．2％、81．3％、74．8％；对照组为97．3％、61．3％、55．2％；术后3年、5年生存率有显差异。治疗组术后并发症为7／40(17．5％)，对照组为5／40(12．5％)，无统计学差异。结论 对大肠癌患进行门静脉化疗安全、操作简单，可有效地降低肝转移发生率，提高患五年生存率。

The Preventing Effect of the Chemotherapy Via Port Vein Infussion on Liver Metastasis in the patients with Large Bowl Cancer

Objective To investigate the effect of the chemotherapy by port vein infusion(PVI) on preventing the patients with large bowl cancer of the stage Dukes B and Dukes C from liver metastasis.Methods After radical resection,80 patients with large bowl cancer were randomly divided into 2 groups.The study group received 5 Fu(1.0 g/d, continuing 7 d) chemotherapy by PVI( n =40),The control group did not receive any chemotherapy( n =40).All patients were followed up.Results The rate of liver metastasis in the study group (8.5%)was lower than that in control group (30.8%);The rates of 3 and 5 year survial in the study group were higher than in control group.The complication had no difference between the two groups.Conclusion 5 Fu chemotherapy by PVI after radical resection in the patients with large bowl cancer may decrease the metastases rate and raise the 3 and 5 year survial rate.This method is safe and simple.