肝细胞肝癌及癌周组织中P~（53）、C－myc基因产物表达的研究

应用免疫组化ＡＢＣ法，对肝癌高发区６２例肝细胞癌组织及癌周肝组织进行了Ｐ５３和Ｃ－ｍｙｃ基因产物的标记。结果显示，肝细胞肝癌组织中Ｐ５３与Ｃ－ｍｙｃ基因蛋白均过量表达，阳性率分别为７４．１９％与６７．７４％，均高于有关文献报道的检测率。癌周肝组织中Ｐ５３与Ｃ－ｍｙｃ阳性检出率均低于癌组织。ＨＢｓＡｇ阳性病例、癌周伴肝硬变病例Ｐ５３与Ｃ－ｍｙｃ基因异常表达率均显著高于相应的阴性病例。本文随访病例中，术后肿瘤复发组Ｐ５３与Ｃ－ｍｙｃ基因表达的阳性率极明显地高于未复发尚生存组。文中还讨论了Ｐ５３和Ｃ－ｍｙｃ基因产物的表达在肝细胞癌发生中的可能作用

Studies of p53 and c-myc gene products expression in huma hepatoccllular carcinoma and adjoent non-neoplastic liver tissue

53 and c- myc gene expression of 62 patients from high liver cancer incidence regions have been marked on theparaffin sections by the ABC method of immunohistochemistry.The results showed that hepatocellular carcinometissues exhibited enhence ment of p53 and c-myc gene expression with positive rates of 74.19%and 67.74% re-spectively.The expression level of p53 and c-myc geng in the surrounding hepatic tissues were lower.The increaseof p53 and c-myc geng expression were closely interre lated whith positivc HBsAg and liver cirrhosis. The p53 andc-myc expression positive rates in the tumor recurrence patients were higher than without tumor recurrence cas-es. We also disoussed the possible function of p53 and c-myc gene products expression in the carcinogenesis ofprimary hepatocellular carcionma.