| 泰兴市枯、丰水期不同水体致突变性与胃、食管和肝癌高发的关系 |
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| 引用本文： | 丁建华,臧宇,吴建中,李苏平,周建农,高长明,苏平,刘燕婷,周学富,王如鸿,丁保国.泰兴市枯、丰水期不同水体致突变性与胃、食管和肝癌高发的关系[J].中华肿瘤防治杂志,2002,9(6):561-563. |
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| 作者姓名： | 丁建华 臧宇 吴建中 李苏平 周建农 高长明 苏平 刘燕婷 周学富 王如鸿 丁保国 |
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| 作者单位： | 1. 江苏省肿瘤防治研究所流行病室,江苏,南京,210009
2. 江苏省泰兴市卫生防疫站,江苏,泰兴,225500 |
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| 基金项目： | 1999年江苏省社会发展基金重点项目资金资助 (BS990 2 6-1) |
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| 摘 要： | 目的 :检测泰兴地区枯水期和丰水期不同水体的致突变性 ,并研究其与当地胃、食管和肝癌发生的相关关系。方法 :采用蚕豆根尖微核试验和慧星实验方法 ,检测泰兴市枯水期 97份和丰水期 10 1份水样的致突变性。结果 :水体致突变性呈塘水 >河水 >井水的规律 ;相同地区水体的致突变性在枯水期比丰水期强 ;枯水期河水和塘水诱发的微核效应与当地肝癌、胃癌和食管癌发病率有高度的正相关 ,而丰水期仅塘水微核效应与胃癌发病率有正相关 ;诱发微核率较高的井水、河水和沟塘水对人淋巴细胞都具有致突变性 ,其中尤以河水为甚。结论 :上述结果提示水源污染与肿瘤的高发可能存在着病因学联系
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| 关 键 词： | 水污染 微核试验 DNA损伤 肿瘤/病因学 |
| 文章编号： | 1009-4571(2002)06-0561-03 |
| 修稿时间： | 2002年6月28日 |
Mutagenicity Of Different Types of Water Body In Taixing During Dry and Rainy Season and Their Relationships With The Incidence Of Stomach, Esophagus and Liver Cancer |
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| DING Jian hua,ZANG Yu,WU Jian zhong et al.Mutagenicity Of Different Types of Water Body In Taixing During Dry and Rainy Season and Their Relationships With The Incidence Of Stomach, Esophagus and Liver Cancer[J].Chinese Journal of Cancer Prevention and Treatment,2002,9(6):561-563. |
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| Authors: | DING Jian hua ZANG Yu WU Jian zhong |
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| Institution: | DING Jian hua,ZANG Yu,WU Jian zhong et al.Department of Epidemiology,Jiangsu Institute of Cancer Research,Nanjing 210009,China |
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| Abstract: | Objective To examine the mutagenicity of different types of water in Taixing during dry and rainy season respectively,and the correlation between the mutagenicity and the occurrence of stomach,esophagus and liver cancer in this area.Methods Altogether 97 water samples in dry season and 101 samples in rainy season were collected,and the mutagenicity was detected by the Vicia faba root tip micronucleus test and comet assay test.Results The mutagenicity of water body displayed a rule of well
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| Keywords: | water pollution micronucleus test DNA injuries neoplasms/etiology |
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