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Oral manifestations of alpha-mannosidosis: report of a case with ultrastructural findings |
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| Authors: | Tetsuro Ishigami rea Schmidt-Westhausen Hans Peter Philipsen Sergei I. Baiborodin Hans Gelderblom Peter A. Reichart |
| Affiliation: | First Department of Oral and Maxillofacial Surgery, Kagoshima University Dental School, Kagoshima, Japan;Abteilung für Oralchirurgie und Zahnärztliche Röntgenologie, Charité, Humboldt-Universität zu Berlin, Berlin, Germany;Oral Biology Unit, University of Hong Kong, Hong Kong;Institute of Cytology and Genetics, Academy of Sciences, Siberian Division, Novosibirsk, Russia;Robert Koch Institut, Bundesgesundheitsamt, Berlin, Germany |
| Abstract: | Alpha-mannosidosis is a rare storage disease with distinct biochemical, clinical, histological and ultrastructural features. The oro-facial findings in a 26-year-old man are described. Gingival and oral mucosal hyperplasias were studied using histology and transmission electron microscopy (TEM). The TEM findings were comparable to those of other tissues examined in previous reports, consisting of histiocytic cells containing storage vacuoles with fine reticule-granular material. |
| Keywords: | giant cells histiocytes hyperplasia lysosomal storage disease mannosidosis |