高糖代谢记忆与糖尿病并发症

高糖"代谢记忆"是影响糖尿病并发症的重要因素,早期血糖控制情况可对并发症产生持久影响.氧化应激和晚期槠基化终末产物(AGEs)是形成高糖"代谢记忆"的基础,同时也是高糖"代谢记忆"参与糖尿病并发症的主要途径.在氧化应激途径中,活性氧簇(ROS)激活与糖尿病并发症相关;在AGEs途径中,AGEs引发的后续效应介导并发症的发生.减弱氧化应激和AGEs的作用,清除有害的代谢记忆,有望成为延缓糖尿病慢性并发症的治疗措施.

Metabolic memory of hyperglycemia and diabetic complications

"Metabolic memory" of hyperglycemia is an important factor affecting diabetic complications. The early glycaemic control has a long-term influence on future complications. Oxidative stress and advanced glycation end-products (AGEs) are the basis of "metabolic memory" ,and they are also the key pathways through which "metabolic memory"of hyperglycemia leads to diabetic complications. In oxidative stress pathway,reactive oxygen species (ROS) are related with diabetic complications,and in AGEs pathway,AGEs triggering the cascade of events may be involved in diabetic complications. Ameliorating the effect of oxidative stress and AGEs,and removing the harmful " metabolic memory" .could be a promising step to prevent diabetic complications.