超敏C反应蛋白在2型糖尿病合并冠心病时的临床意义

【目的】探讨2型糖尿病患者合并冠状动脉狭窄时血中超敏C反应蛋白水平的变化。【方法】2型糖尿病患者118例经选择性冠状动脉造影证实冠状动脉正常者为正常组（32例），冠状动脉狭窄≥50％为冠心病组（86例，占72．88％）。据病变累及血管支数分为单支病变组（22例），双支病变组（28例），三支病变组（36例）。空腹取血检测超敏C反应蛋白水平。【结果】冠心病组超敏C反应蛋白水平（9．44±0．82mg／L）明显高于正常组（3．78±0．60mg／L），两者差异有显著性意义（P〈0．01）。三支病变组超敏C反应蛋白水平（9．88±0．58mg／L）明显高于单支病变组（8．45±0．62mg／L），二者差异有显著性意义（P〈0．01）。【结论】血中超敏C反应蛋白水平在糖尿病合并冠心病时升高，随着病变严重程度增加其水平也随之增高。

Clinical significance of high-sentivity C-reactive protein in patients with type 2 diabetes mellitus complicated with coronary heart disease

Objective] To evaluate the serunm high - sensitivity C-reactive protein （hs-CRP） lever in patient with type 2 diabetes mellitus （T2DM） complicated with severity of coronary arterial lesion in coronary heart disease. Methods] 118 patients of T2DM undergone coronary angiography were divided into the normal group with the normal coronary arterial （32 cases ） and the coronary heart disease group with the arterial obstructions〉50% （ 86 cases, 72. 88%）. Accorting to the numbers of coronary artetial with the lesion , we divided the later groups into single-arterial lesion group, double-arterial lesion group and three arterial lesion group, then observe the change of the serunm high - sentivity C - reactive proteinlever. Results] The lever of serum high-sensivity C-reactive protein in patient of coronary heart disease group （9.44± 0.82 mg/L） were significantly higher than that of in patient of the normal group （3.78 ± 0.60 mg/L） （P 〈 0.01）, And the lever of serum high-sensitivity C-reactive protein in patient of three- arterial lesion group （9.88 ±0.58 mg/L） were higher than that of in patient of single-arterial lesion group （8.45 ±0.62 mg/L）, （P 〈 0.01）. Conclusions] The lever of serunm high-sensitivity C-reactive protein （hs-CRP） will increase in patient with type 2 diabetes mellitus （T2DM） complicated with coronary heart disease. The more severity coronary arterial lesion were, higher the level would.