Residual thymic tissue and lymph node involvement by acute myeloid leukaemia presenting as mediastinal,strongly 18FDG‐PET‐positive masses |
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| Authors: | Georg Maschmeyer Ingo Brink Doris Jähne Renate Arnold Olaf Schega |
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| Affiliation: | 1. Department of Haematology, Oncology and Palliative Care, Klinikum Ernst von Bergmann, Potsdam, Germany;2. Department of Nuclear Medicine, Klinikum Ernst von Bergmann, Potsdam, Germany;3. Institute of Tissue Diagnostics, Helios Klinikum Emil von Behring, Berlin, Germany;4. Bone Marrow Transplant Section, Department of Haematology, Oncology and Tumour Immunology, Charité University Medical School, Berlin, Germany;5. Department of Thoracic Surgery, Johanniter‐Krankenhaus, Treuenbrietzen, Germany |
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| Abstract: | We report on a multidisciplinary management of a 68‐year‐old AML patient presenting with a PET‐positive mediastinal tumour typical for lymph node metastasis. It was removed via minimally invasive thoracoscopic intervention and was identified as a thymus residual infiltrated by AML. Follow‐up PET‐CT scan after resection and remission induction chemotherapy was completely normal. To our knowledge, this is the first documented case report of AML presenting with PET‐positive infiltrates of thymic and lymph node tissue along the aortic bow mimicking a second intrathoracic malignancy. Our observation indicates the usefulness of this imaging technique and supports clarification of these unusual findings in AML patients, in case of need also by invasive diagnostic procedures, to enable an adequate therapeutic decision. |
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| Keywords: | acute myeloid leukemia |
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