Diagnostic performance of contrast-enhanced computed tomography in the immediate assessment of radiofrequency ablation success in colorectal liver metastases |
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Authors: | Christina Schraml Stephan Clasen Nina F. Schwenzer Ingmar Koenigsrainer Tina Herberts Claus D. Claussen Philippe L. Pereira |
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Affiliation: | (1) Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, Tuebingen, 72076, Germany;(2) Department of Abdominal Surgery, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, Tuebingen, 72076, Germany;(3) Department of Medical Biometry, University Hospital of Tuebingen, Westbahnhofstrasse 55, Tuebingen, 72070, Germany |
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Abstract: | Background To determine the accuracy of contrast-enhanced multislice computed tomography (CT) in the assessment of treatment success immediately after CT-guided radiofrequency (RF) ablation. Methods 26 patients with 38 Colorectal liver metastasis (CRM) were treated by CT-guided RF ablation. Pre-contrast and portal phase CT features before and immediately after ablation were retrospectively evaluated quantitatively and qualitatively: Influence of attenuation characteristics, safety margin, congruency between tumor and coagulation, and morphological criteria (shape, margin distinction, margin configuration, and margin continuity) were investigated. Findings were statistically analyzed with regard to local tumor progression. Results Mean observation period for follow-up scans was 6.4 months (range: 3–40 months). Attenuation characteristics, safety margin, and congruency had no significant effect on the probability of local tumor progression. Coagulations whose margin was categorized as “discontinuous” were significantly more often associated with local recurrence (p = 0.038). No significant influence on local recurrence could be detected regarding coagulation shape, margin distinction, and configuration. Conclusion Computed tomography imaging immediately after RF ablation allows for morphological characterization of the coagulation and provides a valid baseline status for follow-up imaging. However, in CRM, morphological image criteria and attenuation characteristics have limited predictive value for immediate detection of persistent tumor. |
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Keywords: | Radiofrequency ablation Computed-tomography Liver Colorectal cancer metastasis Treatment control |
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