头颈部肿瘤放疗中口腔黏膜反应的治疗

目的探讨2种漱口液治疗肿瘤患者在放射治疗过程中急性上口腔黏膜炎的疗效。方法将87例头颈部肿瘤患者按随机数字表法分为2组,自制漱口液组（n=43例）和口泰漱口液组（n=44例）。2组在放疗过程中分别采用自制漱口液和口泰漱口液含漱,每次10mL,4～5次.d-1,自放射治疗开始后1周内使用,连续使用7周。根据RTOG/EORTC急性放射性黏膜炎分级标准对2组患者的疗效及口腔黏膜损伤情况进行比较。结果自制漱口液组有效率高于口泰漱口液组、Ⅲ级急性放射性黏膜炎发生率低于口泰漱口液组（均P〈0.05）。结论头颈部肿瘤患者在放疗过程中口腔黏膜反应是不可避免的,自制漱口液配制简单、价格便宜、疗效确定,在头颈部肿瘤患者放射治疗过程中可作为预防和治疗用药。

Treatment of Oral Mucositis during Radiotherapy for Head and Neck Cancer

Objective To explore the effects of two different gargles on acute oral mucositis during radiotherapy in patients with head and neck cancer.Methods A total of 87 patients with head and neck cancer were randomly assigned to receive either self-made gargle（n=43） or chlorhexidine mouthwash（n=44） within 1 week from the beginning of radiotherapy until week 7（4~5 times per day,10 mL per time）.The curative effect and oral mucosa injury were assessed according to the RTOG/EORTC acute radiation mucositis grading standard.Results Compared with chlorhexidine mouthwash group,the self-made gargle induced an increase in the efficiency and a decrease in the incidence of grade Ⅲ acute radiation mucositis（P〈0.05）.Conclusion Oral mucositis is an inevitable complication of radiation therapy for head and neck cancer.The self-made gargle is simple,cheap and effective in prevention and treatment of radiotherapy-induced oral mucositis in patients with head and neck cancer.