基层医院铜绿假单胞菌医院感染现状及耐药性分析

目的探讨基层医院铜绿假单胞菌医院感染现状及其耐药性,为临床合理用药提供科学依据。方法对2008-2010年大英县人民医院感染性标本中分离的157株铜绿假单胞菌进行21种抗菌药物的体外药敏试验。结果 157株铜绿假单胞菌中痰液标本占60.5%,脓液及分泌物标本占17.2%,各种穿刺标本占12.1%。铜绿假单胞菌对常用抗菌药物的耐药率以亚胺培南最低,其他耐药率较低的还有左氧氟沙星、环丙沙星等,而耐药率〉90.0%的有氨苄青霉素/舒巴坦、氨苄青霉素、阿莫西林/克拉维酸、头孢西丁、加替沙星、复方新诺明。结论大英县人民医院铜绿假单胞菌的医院感染现状已相当严重,具有多药耐药性,须加强监测与控制。

Infection Status and Antibiotic Resistance of Pseudomonas Aeruginosa in Primary Hospitals

ObjectiveTo investigate the infection status and drug resistance of Pseudomonas aeruginosa,and to provide a scientific basis for clinical use of drugs.MethodsIn vitro susceptibility of 157 clinical isolates of Pseudomonas aeruginosa to 21 antimicrobial agents was determined by broth microdilution method in Daying county people＇s hospital between 2008 and 2010.ResultsOf the 157 strains of Pseudomonas aeruginosa,60.5% was isolated from the sputum,17.2% from pus and secretions,and 12.1% from paracentesis specimens.The resistance rates were lowest for imipenem,followed by levofloxacin and ciprofloxacin.More than 90.0% of strains were resistant to ampicillin/sulbactam,ampicillin,amoxicillin/clarithromycin,cefoxitin,gatifloxacin,and cotrimoxazole.ConclusionThe status of Pseudomonas aeruginosa infection is very serious and Pseudomonas aeruginosa shows multidrug resistance to antimicrobial agents.So it is essential to monitor and control Pseudomonas aeruginosa infection in Daying county people＇s hospital.