NT-前端B型脑钠肽对肺心病合并左心功能不全的诊断价值

目的探讨NT-前端B型脑钠肽（NT-proBNP）对老年慢性肺源性心脏病（肺心病）是否合并左心功能不全患者的诊断价值。方法有胸闷气逼的老年慢性肺心病及其合并左心功能障碍的患者40例,按病情将其分为3组：肺心病组16例（A组）;肺心病合并左心收缩功能障碍组12例（B组）;肺心病合并左心舒张功能障碍组12例（C组）。3组均测定血浆NT-proBNP,并行心脏彩超、肺功能等检查。结果与A组比较,B、C组患者血浆NT-proB-NP明显升高（P〈0.05）,B、C组间比较血浆NT-proBNP差异有统计学意义（P〈0.05）。3组肺功能检查差异无统计学意义（P〉0.05）。结论血浆NT-proBNP的高低对于鉴别老年慢性肺心病患者是否合并左心功能障碍有重要的价值。

Diagnostic Value of NT-proBNP in Chronic Cor Pulmonale Complicated by Left Heart Dysfunction

Objective To investigate the diagnostic value of NT-proBNP in elderly patients with chronic cor pulmonale complicated by left heart dysfunction.Methods Forty elderly patients with chronic cor pulmonale complicated by left heart dysfunction who presented with symptoms of breath shortness and chest tightness were divided into three groups：cor pulmonale group（n=16,group A）,cor pulmonale associated with left ventricular systolic dysfunction group（n=12,group B） and cor pulmonale associated with left ventricular diastolic dysfunction group（n=12,group C）.The measurement of plasma NT-proBNP concentrations,echocardiography and pulmonary function tests were performed in all patients.Results Compared with group A,plasma concentrations of NT-proBNP increased obviously in group B and group C,and the differences between the two groups were significant（P0.05）.There were no obvious differences in pulmonary function among the three groups（P0.05）.Conclusion Plasma NT-proBNP concentrations are valuable in differentially diagnosing left heart dysfunction in elderly patients with chronic cor pulmonale.