CD24 expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression |
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Authors: | Alexandra Winkler Richard Zigeuner Peter Rehak Georg Hutterer Thomas Chromecki Cord Langner |
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Institution: | (1) Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria;(2) Department of Urology, Medical University of Graz, Auenbruggerplatz 7, A-8036 Graz, Austria;(3) Research Unit for Biomedical Engineering and Computing, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, A-8036 Graz, Austria |
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Abstract: | Expression of the mucin-like adhesion molecule CD24 has been implicated in the progression of several types of cancer and
has been identified as new prognostic factor. We evaluated CD24 expression in 268 consecutive cases of upper urinary tract
urothelial carcinoma with respect to associations with tumour stage, grade, angioinvasion and infiltrative growth pattern
using a tissue microarray technique and correlated data with patient outcome. CD24 expression was demonstrated in 161/259
(62%) evaluable tumours and was associated with high tumour stage 77/139 (55%) pTa/pT1 vs 84/120 (70%) pT2–pT4; P = 0.02] and high tumour grade 68/139 (49%) low vs 93/120 (78%) high grade; P < 0.001] as well as presence of angioinvasion (P = 0.002) and infiltrative pattern of invasion (P = 0.007). Patients with CD24-positive tumours tended to have a higher risk of disease progression (P = 0.065). Multivariate analysis, however, proved pT stage >1 P < 0.001, risk ratio (RR) = 5.87, 95% confidence interval (CI) = 2.88–11.95] and high tumour grade (P < 0.001, RR = 3.30, 95% CI 1.75–6.22) as only independent predictors of metastatic disease. In conclusion, CD24 expression
in upper urinary tract urothelial cancer is associated with advanced tumour stage and high tumour grade as well as histopathological
features indicative of aggressive tumour behaviour, but it lacks independent impact on patient outcome. |
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Keywords: | Urothelial carcinoma Transitional cell carcinoma Upper urinary tract CD24 Prognosis |
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