Regional myocardial blood volume and flow: First-pass MR imaging with polylysine-Gd-DTPA |
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Authors: | Norbert Wilke Keith Kroll Hellmut Merkle Ying Wang Yukata Ishibashi Ya Xu Jiani Zhang Michael Jerosch-Herold Andreas Muhler Arthur E. Stillman James B. Bassingthwaighte Robert Bache Kamil Ugurbil |
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Abstract: | The authors investigated the utility of an intra-vascular magnetic resonance (MR) contrast agent, poly-L-lysine-gadolinium diethylenetriaminepentaacetic acid (DTPA), for differentiating acutely ischemic from normally perfused myocardium with first-pass MR imaging. Hypoperfused regions, identified with microspheres, on the first-pass images displayed significantly decreased signal intensities compared with normally perfused myocardium (P < 0.0007). Estimates of regional myocardial blood content, obtained by measuring the ratio of areas under the signal intensity-versus-time curves in tissue regions and the left ventricular chamber, averaged 0.12 mL/g ± 0.04 (n = 35), compared with a value of 0.11 mL/g ±0.05 measured with radiolabeled albumin in the same tissue regions. To obtain MR estimates of regional myocardial blood flow, in situ calibration curves were used to transform first-pass intensity-time curves into content-time curves for analysis with a multiple-pathway, axially distributed model. Flow estimates, obtained by automated parameter optimization, averaged 1.2 mL/min/g ±0.5 (n =29), compared with 1.3 mL/min/g ±0.3 obtained with tracer microspheres in the same tissue specimens at the same time. The results represent a combination of T1-weighted first-pass imaging, intravascular relaxation agents, and a spatially distributed perfusion model to obtain absolute regional myocardial blood flow and volume. |
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Keywords: | Contrast agent, blood pool Contrast enhancement Coronary vessels, diseases, 54.76 Heart, flow dynamics Heart. MR. 51.12143 Model, mathematical Myocardium, blood supply, 511.12143 Myocardium, MR, 511.12143 Perfusion studies |
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