| 法尼醇X受体天然激动剂的研究进展 |
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| 引用本文： | 明文华,栾志琳,张晓燕,管又飞. 法尼醇X受体天然激动剂的研究进展[J]. 大连医科大学学报, 2021, 43(3): 244-250. DOI: 10.11724/jdmu.2021.03.11 |
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| 作者姓名： | 明文华 栾志琳 张晓燕 管又飞 |
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| 作者单位： | 大连医科大学医学科学研究院,辽宁大连116044 |
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| 摘 要： | 法尼醇X受体(Farnesoid X receptor,FXR),又称胆汁酸受体,因与代谢调节密切相关,FXR激动剂目前成为代谢性疾病治疗的药物研发热点.FXR天然激动剂来源广泛且大部分具有无或低毒副作用的特点,主要分为动物源性激动剂、植物源性激动剂和微生物源性激动剂三大类.动物源性激动剂包括鹅脱氧胆酸、胆酸、脱氧胆酸...
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| 关 键 词： | 法尼醇X受体 胆汁酸受体 天然激动剂 |
| 收稿时间： | 2020-05-25 |
| 修稿时间： | 2021-05-10 |
Research progress on natural agonists of Farnesoid X receptor |
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| MING Wenhua,LUAN Zhilin,ZHANG Xiaoyan,GUAN Youfei. Research progress on natural agonists of Farnesoid X receptor[J]. Journal of Dalian Medical University, 2021, 43(3): 244-250. DOI: 10.11724/jdmu.2021.03.11 |
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| Authors: | MING Wenhua LUAN Zhilin ZHANG Xiaoyan GUAN Youfei |
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| Affiliation: | Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China |
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| Abstract: | Due to the significant association of Farnesoid X receptor (FXR) with metabolic regulation, FXR agonists have become a hotspot for drug research and development in the treatment of metabolic diseases. FXR natural agonists have a wide range of sources and most of them have the characteristics of no or low side effects. They are mainly divided into three categories:animal-derived agonists, plant-derived agonists and microbial-derived agonists. Animal-derived agonists include endogenous bile acids such as chenodeoxycholic acid, cholic acid, deoxycholic acid, lithocholic acid and ursodeoxycholic acid as well as androsterone; plant-derived agonists include plants and plant extracts, such as Alisma extract, caffeol, couestrol, grape lactone and dioscin; microbial-derived agonists include serotonin. This article reviews the research progress of FXR natural agonists. |
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| Keywords: | Farnesoid X receptor bile acid receptor natural agonist |
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