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Anti-gal-C antibody in autoimmune neuropathies subsequent to mycoplasma infection
Authors:Susumu Kusunoki  Atsuro Chiba  Seiji Hitoshi  Hajime Takizawa  Ichiro Kanazawa
Abstract:Four of 82 patients with Guillain-Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody. © 1995 John Wiley & Sons, Inc.
Keywords:Guillain-Barré   syndrome  multifocal motor neuropathy  galactocerebroside  ganglioside  Mycoplasma pneumoniae
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