雷公藤红素单用和联用抗肿瘤作用机制的研究进展

雷公藤红素是雷公藤中的主要活性成分之一,现代研究表明,雷公藤红素具有广谱、高效的抗肿瘤活性,其抗肿瘤作用机制包括抑制肿瘤细胞增殖、抑制肿瘤细胞转移、诱导肿瘤细胞自噬等作用,同时雷公藤红素联合用药还具有协同增敏、逆转肿瘤多药耐药的作用。综述了近几年雷公藤红素单用及联合用药抗肿瘤的作用机制,此外还总结了目前用于雷公藤红素药物递送系统,并对未来研究方向加以讨论,旨在探明雷公藤红素作用机制,通过联合用药以及改变递药系统提高雷公藤红素抗肿瘤效果,为今后雷公藤红素的研究与应用提供参考,以促进雷公藤红素的研究和临床应用。

Research progress on anti-tumor mechanism of celastrol alone and in combination

Celastrol is one of the main active constituents from Tripterygium wilfordii. Modern studies have shown that celastrol exhibits broad-spectrum and highly effective anti-tumor activity. Its anti-tumor mechanism includes inhibition of tumor cell proliferation, metastasis, autophagy and so on. At the same time, celastrol combined with other drugs also has the effect of synergistic sensitization and reversing tumor multidrug resistance. The anti-tumor mechanism of celastrol alone and in combination are reviewed in recent years in this paper. In addition, the current drug delivery system for celastrol is summarized, and the future research directions are discussed, aiming to explore the mechanism of celastrol, and improve the anti-tumor effect of celastrol by combining drugs and changing the delivery system, which provide a reference for the future research and application of celastrol to promote the research and clinical application of celastrol.