中药单体成分调节肿瘤微环境的研究进展

肿瘤微环境是指肿瘤细胞生长、侵袭和转移的特殊内在环境,分为非免疫和免疫微环境,是一个极其复杂的系统。中药单体成分能够通过改善肿瘤微环境来达到抑制肿瘤的目的,包括抑制血管内皮细胞血管生成、抑制分泌血管内皮生长因子信号的转导、阻止肿瘤相关巨噬细胞的募集和极化、调节自然杀伤细胞的增殖、抑制T细胞中吲哚胺2,3-双加氧酶和成纤维细胞中基因产物的表达、减少骨髓源性抑制细胞的积聚等。综述了中药单体成分对肿瘤微环境中各种细胞调节作用的影响及其作用机制,以期为中药抗肿瘤治疗的临床应用提供新的思路和方法。

Research progress on monomers of traditional Chinese medicine in regulating tumor microenvironment

Tumor microenvironment refers to the special internal environment for the growth, invasion, and metastasis of tumor cells, divided into non-immune and immune microenvironment. It is an extremely complex system. Monomers of traditional Chinese medicine can improve the tumor microenvironment to inhibit tumor growth, including inhibiting angiogenesis and the secretion of vascular endothelial growth factor for signal transduction, attenuating recruitment and polarization of tumor associated macrophage, adjusting proliferation of the natural killer cells, inhibition the expression of indoleamine 2,3-dioxygenase in T cells and gene product in fibroblasts, reducing the accumulation of bone marrow-derived suppressor cells. In this paper, the regulatory effects and mechanisms of monomer components of traditional Chinese medicine on various cells in tumor microenvironment are reviewed, in order to provide new thoughts and methods for clinical application of anti-tumor therapy of traditional Chinese medicine.