Thrombotic Thrombocy openic Purpura: Report of a Case With Possible Immune Etiology |
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| Authors: | Mant, Michael J. Cauchi, Maurice N. Medley, Gabriele |
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| Affiliation: | 1 Departments of Pathology and Medicine, Monash University, Alfred Hospitaland Department of Anatomic Pathology, Alfred Hospital, Melbourne, Australia.
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| Abstract: | Thrombotic thrombocytopenic purpura(TTP) is a disorder of unknown etiology. An immunologic basis has beensuggested, although proof is lacking.The immunologic, hematologic, andautopsy findings in a case of TTP occurring 6 wk postpartum are described.Immunofluorescent studies revealedthe presence of IgM and complement,as well as fibrin in the vicinity of theendothelium and in thrombi in smallblood vessels in multiple organs.These findings suggest an active immunologic process in this case. WhileTTP is probably of diverse etiology,confirmation of these findings infurther cases would provide a rationalbasis for the use of immunosuppressive therapy. Submitted on January 31, 1972 Revised on March 30, 1972 Accepted on April 26, 1972 |
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