Survivin 在胆囊癌组织中的表达及与病理的关系

目的　观察Survivin在胆囊癌中的表达情况以及与病理的关系。方法　应用免疫组织化学方法分析我院 2 0 0 1年 1月～ 2 0 0 3年 12月间行胆囊癌切除的 2 4例胆囊癌标本Survivin的表达情况 ,并分析其表达水平与肿瘤病理分期和分级之间的关系。结果　 2 4例胆囊癌标本中有 17例Survivin表达阳性 ,占总数的 70 .8%。Survivin在Ⅳ、Ⅴ期胆囊癌中的阳性率分别为 87.5 %和10 0 % ,表达水平明显比Ⅰ期 (3 3 .3 % ) ,Ⅱ期 (60 .0 % ) ,Ⅲ期 (66.7% )的高 (P <0 .0 5 ) ,在不同分化程度的胆囊癌中的表达水平不同 (P <0 .0 5 ) ,而阳性率未见明显不同 (P >0 .0 5 )。结论　Survivin在多数胆囊癌中阳性表达 ,并且其表达阳性率和表达强度均与肿瘤的病理分期呈正相关

Expression of survivin in gallbladder carcinoma and its relationship to the pathological stage

Objective To elucidate the expression of survivin in gallbladder carcinoma and its relation to the pathology.Methods The expression of survivin in gallbladder carcinoma tissues from January 2001 to December 2003 studied using immunohistochemical analysis a,the relationship between the expression and pathological stage,histological differentiation grade of the tumor analysed retrospectively.Results Survivin was expressed in 17 of 24 (70.8%) cases of human gallbladder carcinoma tissues.The expression of surviving had significantly relaed to the tumor stage,and the positive rate and level of survivin expression was significantly higher in the advanced stages (P< 0.05).The positive level was higher in high grade lesion,but positive rate was not related to histological differentiation grade.Conclusion Survivin expressed in the most gallbladder carcinoma,and up-regulated especially in the advanced pathological stage.The relationship to the histological differentiation grade need further study.