| 乳腺癌新辅助化疗对ER、PR和C—erbB-2的影响及意义 |
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| 引用本文： | 邹力君.乳腺癌新辅助化疗对ER、PR和C—erbB-2的影响及意义[J].现代保健,2011(17):18-19. |
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| 作者姓名： | 邹力君 |
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| 作者单位： | 河南省平顶山市第一人民医院,467000 |
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| 摘 要： | 目的讨论乳腺癌新辅助化疗（NAC）对雌激素受体（ER）、孕激素受体（PR）和C—erhB-2的影响及意义。方法对2006年1月～2009年1月收入笔者所在医院进行乳腺癌治疗的96例患者在知情同意情况下进行新辅助化疗，使用免疫组化S—P试剂盒检测化疗前后96例患者的ER、PR和C—erbB－2表达有无变化。结果接受新辅助化疗后，患者的ER、PR、C—erbB－2表达水平无统计学意义（P〈0．05），发生变化的仅分别为13、18、16例。结论新辅助化疗对乳腺癌患者的ER、PR、C—erbB－2表达水平无明显影响。
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| 关 键 词： | 乳腺癌 新辅助化疗 ER PR C—erbB-2 |
Effect and dinical significance of neoadjuvant chemotherapy on expressions of ER, PR and C - erbB - 2 in breast cancer tissues |
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| Institution: | ZOU Li -jun. The First People＇s Hospital of Pingdingshan, Pingdingshan 467000, China |
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| Abstract: | Objective To study the influence of neoadjuvant chemotherapy on expression of ER, PR and C - erbB - 2. Methods The expressions of ER.PR and C - erbB - 2 of 96 patients with breast cancer were investigated by SP immunohistochemieal method before and after Neoadjuvant Chemotherapy,whom were treated by Neoadjuvant Chemotherapy from jan- uary 2006 to january 2009 in our hospital. Results The difference of ER, PR and C - erbB - 2 before and after neoadjuvant chemotherapy were insignificant （ P 〉 0. 05 ） Only changes are 13,18 and 16 cases. Conclusion Neoadjuvant chemotherapy could not reduce the expression of ER ,PR and C -erbB -2 significantly. |
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| Keywords: | Breast cancer Neoadjuvant chemotherapy ER PR C - erbB - 2 |
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