Detection of particles within the nasal airways during respiration |
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| Authors: | T Keck R Leiacker M Klotz J Lindemann H Riechelmann G Rettinger |
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| Institution: | Department of Otorhinolaryngology, University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany e-mail: tilman.keck@medizin.uni-ulm.de, Tel.: +49-731-5027501, Fax: +49-731-5026703, DE
Klotz-Lasertechnologien in der Medizin-, Me?- und Umwelttechnik, Bad Liebenzell, Germany, DE
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| Abstract: | This study introduces a new experimental set-up for particle detection within the nasal airways and describes intranasal
deposition of particles at various regions of the nasal cavity and the nasopharynx. During respiration of an aerosol of starch
particles the nondeposited particles in the air were detected in 11 volunteers by a transnasally placed suction probe at numerous
sites of the nasal cavity and nasopharynx. Another, identical suction probe measured the initial number of inhaled particles
at the nostril. The two suction probes were connected to two identical laser particle counters and allowed calculation of
particle deposition. Particles 1–3 μm in size were deposited to about 60% within the entire nasal cavity, whereas most of
the particles 4–30 μm in size were deposited within the entire nasal cavity. Between 80% and 90% of the particles retained
in the nasal cavity were deposited at the anterior nasal segment. Studies on deposition of various drugs within the nasal
cavity using this experimental set-up are conceivable.
Received: 29 May 2000 / Accepted: 10 August 2000 |
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| Keywords: | Particle deposition Intranasal measurement Aerosol Regional intranasal particle mapping |
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