| 中波紫外线与皮肤鳞状细胞癌发生机制研究进展 |
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| 引用本文： | 李艳茹,王晓彦. 中波紫外线与皮肤鳞状细胞癌发生机制研究进展[J]. 医学综述, 2008, 14(19): 2921-2924 |
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| 作者姓名： | 李艳茹 王晓彦 |
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| 作者单位： | 内蒙古医学院第一附属医院皮肤科,呼和浩特,010059 |
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| 摘 要： | 皮肤鳞状细胞癌是常见的恶性皮肤肿瘤之一。而紫外线是诱发鳞癌的主要因素,但其诱发皮肤癌的确切机制尚未完全阐明。其中中波紫外线对角质形成细胞的DNA损伤是诱发皮肤癌的基础。p53、Fas/FasL、砷及免疫抑制等因素在中波紫外线诱导的鳞癌发生过程中发挥着重要的作用。机体对中波紫外线造成的光损伤又有多种修复途径。
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| 关 键 词： | 中波紫外线 皮肤鳞状细胞癌 基因突变 免疫抑制 |
Research Development of UVB in occurrence mechanism of Cutaneous Squamous Cell Carcinoma |
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| LI Yan-ru,WANG Xiao-yan. Research Development of UVB in occurrence mechanism of Cutaneous Squamous Cell Carcinoma[J]. Medical Recapitulate, 2008, 14(19): 2921-2924 |
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| Authors: | LI Yan-ru WANG Xiao-yan |
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| Affiliation: | LI Yan-ru,WANG Xiao-yan.(Department of Dermatology,the First Affiliated Hospital,Inner Mongolia Medical College,Huhhot 010059,China) |
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| Abstract: | Cutaneous squamous cell carcinoma (SCC)is one of common malignant skin tumors.Ultraviolet B (UVB)is a main reason inducing SCC.The accurate occurrence mechanism of SCC is still unclear by now.UVB-induced skin DNA damage is the foundation which can induces SCC.The human body can repair UVB-induced skin damage by some ways.Many factors play an important role in UVB-induced SCC,such as P53,Fas/FasL,Arsenite,immuno-suppression and so on. |
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| Keywords: | Ultraviolet B Squamous cell carcinoma Gene mutation Immunosuppression |
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