紫杉醇、顺铂联合氟尿嘧啶方案治疗晚期胃癌的临床观察

目的研究紫杉醇（PTX）、顺铂（DDP）联合氟尿嘧啶（5-Fu）治疗晚期胃癌的近期疗效和毒副作用。方法晚期胃癌31例，PTX150mg·m^-2，静滴3h，第一天；DDP20mg·m^-2，第1—5d静滴；5-Fu500mg·m^-2，第1．5d静滴。以上方案每4周重复，2个周期后评价疗效。结果31例晚期胃癌总有效率64．5％，其中CR2例（6．5％），PR18例（58．1％）。主要毒性反应为骨髓抑制和消化道反应。结论PTX、DDP联合5-Fu对晚期胃癌近期效果显著，毒副反应较小。

Clinical observation of paclitaxel,cisplatin combined with fluorouracil therapy with advanced gastric cancer

Aim To observe short term effect and adverse reaction of paclitaxel(PTX),cisplatin(DDP)combined with fluorouracil(5-FU)for the treatment of patients with advanced gastric cancer.Methods Thirty-one patients with advanced gastric cancer were treated with PTX 150 mg·m2 dropping 3 hours d1,DDP 20 mg·m-2 dropping d1-5,5-Fu 500 mg·m-2 dropping d1-5.The regimen was repeated every 4 weeks.The efficacy was evaluated after 2 cycles.Results The total effective rate was 64.5% in the 31 patients with advanced gastric cancer,including 2 cases CR and 18 cases PR.The main toxicity were myelosuppression and alimentary canal reactions.Conclusion PTX,DDP combined with 5-Fu can achieve remarkable effect in patients with advanced gastric cancer and toxicity is low.