| 吡嘧司特钾水凝胶骨架缓释片的研究 |
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| 引用本文： | 姚瑶,丁燕飞,刘文,李进华. 吡嘧司特钾水凝胶骨架缓释片的研究[J]. 中国新药杂志, 2003, 12(8): 632-635 |
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| 作者姓名： | 姚瑶 丁燕飞 刘文 李进华 |
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| 作者单位： | 1. 中南大学药学院,长沙,410078
2. 中南大学药学院97级实习生,长沙,410078 |
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| 摘 要： | 目的研制吡嘧司特钾(TBX)水凝胶缓释骨架片.方法以羟丙甲基纤维素(HPMC)为骨架材料,考察HPMC用量、黏度及压片压力等对主药体外释放速度的影响,优化处方工艺.结果所得片剂体外释放实验表明10h累积释放度＞75%,其释放行为符合Hguchi方程.HPMC的用量、黏度、制备方法及压片片力的大小等对TBX的释放速率均有显著影响.结论用高黏度的HPMC作为亲水凝胶骨架片的基质能达到较好的缓释作用.
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| 关 键 词： | 吡嘧司特钾 缓释片 羟丙甲基纤维素 药物释放度 |
| 文章编号： | 1003-3734(2003)08-0632-04 |
The study on hydrophilic gel matrix sustained-release tablets of pemirolast potassium |
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| YAO Yao ,DING Yan-fei ,LIU Wen ,LI Jin-hua. The study on hydrophilic gel matrix sustained-release tablets of pemirolast potassium[J]. Chinese Journal of New Drugs, 2003, 12(8): 632-635 |
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| Authors: | YAO Yao DING Yan-fei LIU Wen LI Jin-hua |
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| Affiliation: | YAO Yao 1,DING Yan-fei 1,LIU Wen 2,LI Jin-hua 2 |
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| Abstract: | Objective:To prepare HPMC hydrophilic gel matrix tablets containing pemirolast potassium(TBX) as a sustained-release preparations.Methods:The effects of the amount and viscosity of hydroxyopyll-methlcellulose(HPMC),compressing pressure and additives on the drug release from the matrix tables were observed.Results:Those factors can influence the release of TBX from HPMC hydrophilic matrix tablets.The accumulated release amount of TBX sustained tablet was more than 75% within 10 hours.The drug release pattern was in accord ance with the Higuchi equation.Conclusion:The higher viscosity HPMC matrix tablets of TBX can be used as a barrier to prepare a matrix sustained-release tablet of TBX. |
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| Keywords: | pemirolast potassium sustained-release tablets hydroxyopyl-methylcellulose releasing rate |
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