骨瓜提取物致过敏性休克36例文献分析

目的：探讨骨瓜提取物致过敏性休克的临床特点及发生规律，为临床合理用药提供参考。方法：以“骨瓜提取物”、“休克”、“过敏反应”为关键词进行检索，对文献中的有关数据进行统计与分析。结果：检索到骨瓜提取物致过敏性休克文献29篇，病例36例。骨瓜提取物在近两年引起过敏性休克25例，占69.4%，75.0%的过敏性休克发生在首次用药过程中，66.7%发生在用药开始后的10 min内。结论：骨瓜提取物注射剂导致过敏性休克发生时间短，病情危重，应引起临床高度重视。

Literature Analysis of 36 Cases of Anaphylactic Shock Induced by Gugua Extractives

Objective：To investigate the clinical features and the regularity of anaphylactic shock induced by gugua extractives so as to provide a reference for rational drug use.Methods：To retrieve the case reports of anaphylactic shock induced by gugua extractives by key words searching and the data was analyzed statistically. Results：About 29 articles including 36 cases reported the anaphylactic shock caused by gugua extractives. About 25 cases （69.4%） of anaphylactic shock were caused by gugua extractives in the recent two years and 75.0%of anaphylactic shock occurred in the process of the first time using gugua extractives and 66.7% of the reactions happened within 10 minutes of the drug administration. Conclusion：The anaphylactic shock caused by gugua extractives usually occurred in a short time but with critical conditions. It should arouse more attention by clinicians.