DNA damage effects of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats |
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| Authors: | Xia Qinghua Hu Panlin Chen Daoda Zhang Jianpin Tian Yuan Zhang Jinghui |
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| Affiliation: | (1) Department of General Surgery, Xiehe Hospital, Tongji Medical University, 430022 Wuhan;(2) Departmnet of General Surgery, Puqi People’s Hospital, 437300 Puqi |
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| Abstract: | To explore the anticancer mechanism and DNA damages of hydroxyapatite ultrofine powder (HAUFP) on lymphocytes of rats, DNA damages in W 256 sarcoma cells and lymphocytes of rats were measured by single cell gel electrophoresis (SCGE). The results showed that HAUFP damaged DNA of W 256 sarcoma cells obviously but only cause slight damage of DNA of lymphocytes in rats. It is suggested that HAUFP selectively damaged DNA of tumor cells with only mild damage of lymphocyte DNA. HAUFP has powerful anticancer effect and little genetic toxicity. |
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| Keywords: | hydroxyapatite ultrofine powder DNA damage anticancer effect rats |
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