趋化因子在子宫内膜异位症发病机制中的作用

子宫内膜异位症（EMs）是妇科常见疾病之一,表现为具有活性的子宫内膜组织出现在子宫腔以外的部位,并具有生长和侵袭的能力,以慢性盆腔痛、痛经及不孕为主要症状,发病率逐年上升。关于其发病机制,尽管提出了很多假说,但其确切的发病机制仍不十分清楚,炎症反应、免疫异常是其发病的病理基础,黏附、侵袭、血管生成是其发生、发展的基本环节。最近的研究显示,趋化因子参与子宫内膜异位种植过程中趋化、黏附、侵袭、血管形成及细胞生长分化等多个重要环节。现就趋化因子在EMs的发生发展中的作用做一综述。

The Action of Chemokines in the Pathogenesis of Endometriosis

Endometriosis is one of the common gynecological diseases defined by the presence, growth, and invasion of endometrial tissue outside the uterine cavity. It is mainly associated with chronic pelvic pain, dysmenorrhe and infertility and its prevalence increases year by year. Although many hypotheses have been proposed, the etiology of the disease remains an enigma. Inflammation and dysimmunity are important pathologic basis of endometriosis, Attachment-aggression-angiogenesis is the basic step of occurrence and development of EMs. Recent studies have suggested that the chemokines are involved in cultivation of endometriosis in the course of chemokine, adhesion, invasion, angiogenesis and cell proliferation and apoptosis and other important links. In this article, we make the review on the roles of ehemotactic factor in occurrence and development of EMs.