| 香烟烟雾对雄性大鼠性功能影响的实验研究 |
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| 引用本文： | 占习双,吴天鹏,欧阳海,刘小兵,蔡惠丽.香烟烟雾对雄性大鼠性功能影响的实验研究[J].中华男科学杂志,2009,15(9):788-791. |
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| 作者姓名： | 占习双 吴天鹏 欧阳海 刘小兵 蔡惠丽 |
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| 作者单位： | 1. 武汉大学,人民医院泌尿外科,湖北,武汉,430060
2. 武汉大学,中南医院血液科,湖北,武汉,430060 |
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| 基金项目： | 湖北省教育厅重点资助项目(2008CDB209)~~ |
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| 摘 要： | 目的:研究香烟烟雾对雄性大鼠性功能的影响。方法:30只SD雄性大鼠随机均分为两组,吸烟组制备大鼠吸烟模型,使用市售红金龙过滤咀香烟(每支焦油含量13mg),吸烟组每日使其被动吸烟4次,每次两支,每次30min持续60d;对照组正常饲养。实验结束前1周两组动物笼中分别放入5只雌性大鼠,采用24h监控录像监测观察骑跨动作1周,60d后处死取标本。测定大鼠血中睾酮水平及阴茎海绵体组织一氧化氮合酶(NOS)的活性,行阴茎海绵体组织的Masson染色图像分析。结果:吸烟组大鼠骑跨动作次数减少,血中睾酮水平明显降低(P<0.05),阴茎海绵体组织NOS活性及平滑肌面积显著降低(P<0.05),胶原纤维明显增加,海绵窦血管腔有明显变化。结论:吸烟组大鼠阴茎勃起功能受到明显影响,睾酮水平降低及阴茎海绵体组织NOS活性降低、阴茎海绵体平滑肌面积的减少可能是其重要的发病机制。
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| 关 键 词： | 吸烟 勃起功能障碍 睾酮 阴茎海绵体平滑肌 一氧化氮合酶 |
Cigarette Smoke Affects Sexual Function of Male Rats |
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| ZHAN Xi-shuang,WU Tian-peng,OUYANG Hai,LIU Xiao-bing,CAI Hui-li.Cigarette Smoke Affects Sexual Function of Male Rats[J].National Journal of Andrology,2009,15(9):788-791. |
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| Authors: | ZHAN Xi-shuang WU Tian-peng OUYANG Hai LIU Xiao-bing CAI Hui-li |
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| Institution: | ZHAN Xi-shuang, WU Tian-peng , OUYANG Hai , LIU Xiao-bing , CAI Hui-li( 1. Department of Urology, Ren Min Hospital, 2. Department of Hemotology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, Hubei 430060, China) |
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| Abstract: | Objective:To study the effect of cigarette smoke on the sexual function of male rats. Methods: Based on Ozyurt's smoking model,we equally divided 30 male adult Sprague-Dawley rats into a control and a smoking group,and exposed the latter to cigarette smoke for 60 days. A week before the end of the experiment,we added 5 female rats to each group and observed their mating through 24-hour video surveillance. Sixty days later,all the rats were killed for the determination of the level of testosterone (T) in the... |
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| Keywords: | smoking erectile dysfunction testosterone corporal cavernosum smooth muscle nitric oxide synthase |
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