云南灯盏花注射液改善血液流变学及TCD的观察

目的观察灯盏花注射液对缺血性脑血管病血液流变学及经颅多普勒（ＴＣＤ）的影响。方法９０例缺血性脑血管病患者随机分成２组，４５例用灯盏花注射液４０ｍｌ加入液体２５０ｍｌ中静脉滴注，每日一次，２０天为一疗程；４５例以复方丹参注射液治疗作对照。观察灯盏花治疗后血液流变学和ＴＣＤ的改善情况。结果灯盏花能明显降低血浆粘度、红细胞聚集指数、血细胞比容，（ｔ＝２．５９，Ｐ＜０．０５，ｔ＝３．４８．Ｐ＜０．０５，ｔ＝２．２９，Ｐ＜０．０５），ＴＣＤ的平均速度、频谱、频窗明显改善。结论灯盏花可降低血粘度、活血化瘀、扩张血管、改善脑微循环及脑供血，其疗效明显优于丹参注射液，是防治缺血性脑血管病较理想的药物。

OBSERVATION OF DENGZHANHUA INJECTIO ON IMPROVEMENT OF HEMORHEOLOGY AND TCD

Objective:To observe effects of Dengzhanhua injectio(DAHI) on hemorheology and transocranial Doppler(TCD).Methods:90 patients with ischemic cerebral vessel disease(IVCD) were randomly divided into 2 groups:DAHI treatment group and Danshen injectio(DSI) treatment group.45 patients were given intravenous drip of DIHI(40ml) and liquid(250ml) every day. A treatment course was 20 days.DSI was used as control.Condition of hemorheology and TCD with DZH Itreatment was observed.Results:DZHI obviously reduced blood viscosity,erythrocyte aggregation hematocrit and improved average velocity(Vm),frequency spectrum and frequency window TCD.Conclusions:It may reduce blood viscosity,huo xue hua xu,dilate vessel,improve cerebral microcirculation and cerebral blood supply.DZHI's effect is better than DSI's.Therefore, DZHI is a ideal drug to prevent ICVD.