| 人工高眼压家兔血液,虹膜及房水cAMP,cGMP含量的关系 |
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| 作者姓名： | Xu Y Liu J Yu C |
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| 作者单位： | 中国医科大学附属第一医院眼科，解放军第二○二医院眼科，中国医科大学基础医学院 |
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| 摘 要： | 目的研究家兔血液、虹膜及房水中环腺苷酸（ｃｙｃｌｉｃａｄｅｎｏｓｉｎｅｍｏｎｏｐｈｏｓｐｈａｔｅ，ｃＡＭＰ）和环鸟苷酸（ｃｙｃｌｉｃｇｕａｎｏｓｉｎｅｍｏｎｏｐｈｏｓｐｈａｔｅ，ｃＧＭＰ）含量与高眼压之间的关系。方法用放射免疫方法测定家兔血浆、虹膜和房水中ｃＡＭＰ、ｃＧＭＰ含量。结果ｃＡＭＰ含量（ｎｍｏｌ／Ｌ）：血浆为７２．８１±７．６７，虹膜为１４１．０８±１６．７０，房水中为２８．４０±０．４９；ｃＧＭＰ含量（ｎｍｏｌ／Ｌ）：血浆为１０．３７±６．１５，虹膜为３５．６４±７．０２，房水中为１２．９０±０．６１。ｃＡＭＰ含量高于对照组（Ｐ＜０．０１），ｃＧＭＰ低于对照组（Ｐ＜０．０１）。结论高眼压与ｃＡＭＰ、ｃＧＭＰ含量关系显著。
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| 关 键 词： | 高眼压 虹膜 环腺苷酸 环鸟苷酸 |
Quantitative analysis of cAMP and cGMP in the plasma, iris and aqueous humor in rabbits with high intraocular pressure |
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| Xu Y,Liu J,Yu C.Quantitative analysis of cAMP and cGMP in the plasma, iris and aqueous humor in rabbits with high intraocular pressure[J].Chinese Journal of Ophthalmology,1997,33(6):433-435. |
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| Authors: | Xu Y Liu J Yu C |
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| Institution: | Department of Ophthalmology, First Affiliated Hospital, China Medical University, Shenyang. |
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| Abstract: | OBJECTIVE: To study the relationship between the levels of cyclic adenosine monophosphate (cAMP), cyclic guanosine monophos-phate (cGMP) in the plasma, iris and aqueous humor and high intraocular pressure in rabbits. METHODS: The quantitative tests of cAMP and cGMP from rabbits were carried out by radioimmunoassay technique. RESULTS: The results showed that there were 72.81 +/- 7.67, 141.08 +/- 16.70 and 28.40 +/- 0.49 of cAMP (nmol/L), and there were 10.37 +/- 6.15, 35.64 +/- 7.02 and 12.90 +/- 0.61 of cGMP (nmol/L) in the plasma, iris and aqueous humor respectively. The levels of cAMP were higher than those in the same samples from the animals as controls (P < 0.01), while the levels of cGMP were less than controls (P < 0.01). CONCLUSION: High intraocular pressure may be significantly associated with the levels of cAMP and cGMP. |
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| Keywords: | High intraocular pressure Iris Cyclic adenosine monophosphate Cyclic guanosine monophosphate |
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