准分子激光角膜切削术后皮质类固醇激毒的应用

比较准分子激光角膜切削术（ｐｈｏｔｏｒｅｆｒａｃｔｉｖｅｋｅｒａｔｅｃｔｏｍｙ，ＰＲＫ）后皮质 类固醇激光素的应用方法。方法应用ＮｉｄｅｋＥＣ５０００型准分子激光机对６００只近眼行ＰＲＫ，术后随机分为Ａ组和Ｂ组，分别采用不同的方法应用皮质类固醇激素，随访６个月。

The application of corticosteroid following photorefractive keratectomy]

OBJECTIVE: The application methods of corticosteroid following excimer laser photorefractive keratectomy (PRK) were compared. METHODS: PRK was performed on 600 myopic eyes with Nidek-EC 5000 PRK System, and then randomly they were divided into group A (228 eyes) and B (372 eyes). Different methods of application of corticosteroid were performed in the two groups. The follow-up period was 6 months. RESULTS: After 6 months of follow-up, the rate of uncorrected visual acuity > or = 0.8 or > or = 1.0 was 97.9%, 93.2% in group A and 98.6%, 93.5% in group B, respectively. Transient ocular hypertension occurred in 2.2% in group A and 2.7% in group B, but the difference was statistically not significant (P > 0.05), the rate of haze greater than grade 1 was 18.4% in group A and 5.4% in group B, with statistically significant difference (P < 0.05). CONCLUSION: After PRK, the appropriate application of corticosteriod can effectively reduce the rate of haze formation and regression towards myopia caused by haze. Powerful corticosteroid used at postoperative early stage and its low concentration at later stage can reduce the incidence of corticosteroid ocular hypertension.