| 微量地塞米松对小鼠胚胎纤维母细胞分裂增殖的影响 |
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| 引用本文： | 朱志忠.微量地塞米松对小鼠胚胎纤维母细胞分裂增殖的影响[J].中华眼科杂志,1997,33(4):304-306. |
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| 作者姓名： | 朱志忠 |
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| 作者单位： | 上海医科大学中山医院眼科 |
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| 摘 要： | 目的研究地塞米松的药物剂量与小鼠胚胎纤维母细胞（ｍｏｕｓｅｅｍｂｒｙｏｆｉｂｒｏｂｌａｓｔｓ，ＭＥＦ）生长增殖之间的相关关系。方法采用细胞培养方法观察不同浓度的地塞米松对ＭＥＦ的影响。结果５０μｇ／ｍｌ（０．００５％）的地塞米松在４８～７２小时内，使ＭＥＦ的细胞计数比对照组减少１６％～２６％，而１～１０μｇ／ｍｌ（０．０００１％～０．００１％）的地塞米松对ＭＥＦ无明显的抑制作用。结论微量地塞米松对纤维母细胞和伤口修复无明显的抑制作用
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| 关 键 词： | 地塞米松 细胞.培养的 |
The effect of minimal dexamethasone on the rate of growth of mouse embryonic fibroblasts in vitro |
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| Zhu Zhizhong.The effect of minimal dexamethasone on the rate of growth of mouse embryonic fibroblasts in vitro[J].Chinese Journal of Ophthalmology,1997,33(4):304-306. |
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| Authors: | Zhu Zhizhong |
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| Institution: | Department of Ophthalmology, Zhongshan Hospital, Shanghai Medical University. |
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| Abstract: | OBJECTIVE: To study of the relationship between inhibition of the growth rate of mouse embryonic fibroblasts (MEF) and the dosage of dexamethasone. METHOD: Cell culture. RESULTS: The effect was observed from 48 to 72 hours after addition of 50 micrograms/ml (0.005%) dexamethasone. In comparison with the control, the number of MEF was cut down by 16%-26%, whereas the addition of dexamethasone between 1 microgram/ml and 10 micrograms/ml (0.0001-0.001%) had no significant effect on the rate of growth of MEF. CONCLUSION: The minimal dosage of dexamethasone has no significant inhibitory effect on the growth rate of fibroblasts and wound healing. |
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| Keywords: | Dexamethasone Cells cultured |
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