氩激光虹膜切除术后房水内SOD和PGE2变化与眼压的关系

目的探讨氩激光虹膜切除术后暂时性眼压升高的发生机制。方法观察家兔氩激光虹膜切除术后１５分钟、６０分钟、６小时、２４小时和４８小时眼压及房水内前列腺素Ｅ２（ｐｒｏｓｔａｇｌａｎｄｉｎＥ２,ＰＧＥ２）浓度和超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ,ＳＯＤ）活性的变化及术前应用消炎痛、可的松、维生素Ｅ、维生素Ｃ等药物对术后暂时性眼压升高的影响。结果激光术后暂时性眼压升高均发生在术后６小时内,眼压升高的同时伴有房水内ＰＧＥ２浓度增加和ＳＯＤ活性显著下降。术前各用药组术后暂时性眼压升高的幅度明显降低。眼部各滴药组术后房水内ＰＧＥ２浓度无明显增加,肌注组术后房水内ＳＯＤ活性无显著下降。结论氩激光虹膜切除术后暂时性眼压升高与术后房水内ＰＧＥ２浓度增加和ＳＯＤ活性下降有关,术前应用消炎痛、可的松及维生素Ｅ、维生素Ｃ等药物对术后暂时性眼压升高有防治作用。

The relation of the changes of SOD and PGE2 in aqueous humor with the transient rise of intraocular pressure after argon laser iridectomy

OBJECTIVE: To study the mechanism of transient rise of the intraocular pressure (IOP) after argon laser iridectomy (ALI). METHODS: The rabbit changes of IOP, the activity of superoxide dismutase (SOD) and the concentration of prostaglandin E2 (PGE2) in aqueous 15 min, 60 min, 6 hr, 24 hr, 48 hr after ALI, the relationships of these changes with the transient rise of IOP, and the effects of using indomethacin, cortisone, vitamin E and C before ALI on the transient rise of IOP were observed. RESULTS: After ALI, the transient rise of IOP took place within postoperative 6 hr. Following the postoperative transient rise of IOP, the concentration of PGE2 in the aqueous was markedly increased, but the activity of SOD in the aqueous markedly decreased. When indomethacin, cortisone, vitamin E and C were used before ALI, the concentration of PGE2 was not markedly increased, the activity of SOD was not markedly decreased and the postoperative transient rise of IOP did not take place. CONCLUSIONS: The transient rise of IOP after ALI is related to the increase of concentration of PGE2 and the decrease of activity of SOD in the aqueous. Using indomethacin, cortisone, vitamin E and C before ALI can effectively prevent the postoperative transient rise of IOP.