肝移植术后患者焦虑和抑郁状况及其影响因素分析

目的 探讨肝移植术后患者的焦虑和抑郁状况及其影响因素.方法 用焦虑自评量表(SAS)和抑郁自评量表(SDS)分别调查2005年1月至2008年12月在中山大学附属第三医院肝脏移植中心接受肝移植术并随访的肝移植患者53例(肝移植组)和同期在本院肝病内科住院治疗的良性终末期肝病患者48例(良性肝病组)的焦虑和抑郁状况,与国内SAS和SDS常模进行比较,并用多元逐步回归分析方法探讨其影响因素.结果 肝移植组、良性肝病组和国内常模的SAS评分分别为(42 ±9)分,(47±11)分和(30±10)分,SDS的评分分别为(48±11)分,(52±11)分和(33±9)分.三组间SAS评分差异有统计学意义(P＜0.01),肝移植组和良性肝病组SAS评分高于国内常模(P＜0.01),肝移植组SAS评分低于良性肝病组(P＜0.05).三组间SDS评分差异有统计学意义(P＜0.01),肝移植组和良性肝病组SDS评分高于国内常模(P＜0.01),肝移植组SDS评分低于良性肝病组(P＜0.05).肝移植术后患者SAS的主要影响因素是年龄(P＜0.01),SDS的主要影响因素是家庭人均月收入(P＜0.05).结论 肝移植术后患者的焦虑和抑郁水平高于一般人群,其影响因素分别是患者的年龄和家庭人均月收入.

Anxiety and depression for liver transplant recipients and their impact factors

Objective To investigate the status of anxiety and depression for liver transplant (LT) recipients and explore their impact factors.Methods During the period of January 2005 to December 2008,the symptoms of anxiety and depression for 53 post-LT recipients ( LT group) and 48 patients with benign end-stage liver disease ( BELD group) were assessed by the self-rating anxiety scale (SAS) and the selfrating depression scale (SDS).And they were compared with that of domestic norm ( Norm group).The impact factors of anxiety and depression for LT recipients were analyzed by stepwise logistic regression.Results The anxiety scores of LT,BELD and Norm groups were (42 ± 9),(47 ± 11 ) and (30 ± 10) and the depression scores of three groups (48 ± 11 ),(52 ± 11 ) and (33 ±9) respectively.The anxiety score was different significantly among three groups(P＜0.01 ).It was higher in the LT and BELD groups than that in the Norm Group( P ＜0.01 )while it was lower in the LT group than that in the BELD group(P ＜0.05).The depression scores were different significantly among three groups(P ＜0.01 ).It was higher in the LT and BELD groups than that in the Norm Group.And it was lower in the LT group than that in the BELD group ( P ＜ 0.05 ).The impact factor of anxiety for LT recipients was patient age and that of depression per capita monthly family income.Conclusion The level of anxiety and depression of post-LT recipients is higher than that of domestic norm.The main impact factor for post-LT anxiety is patient age and that of depression per capita monthly family income.