骨质疏松性骨折椎体成形术后的疗效影响因素

目的 探讨经皮椎体成形术(PVP)治疗骨质疏松性椎体压缩骨折(OVCF)患者的中-远期疗效及影响疗效的因素.方法 2005年3月至2009年12月间以相同的研究标准对131例OVCF患者进行前瞻性研究,以Visual Analog Scale (VAS)、Roland-Morris Disability Questionnaire (RDQ)及患者的活动水平数据评价治疗效果并分析影响中-远期疗效的因素.结果 患者术后的VAS、RDQ评分或活动水平均得到明显改善(均P＜0.05);单、多因素分析显示年龄、单次骨折椎体数、术后活动水平及出现新发骨折均与中-远期疗效差异有统计学意义(P =0.043、0.007、0.001和0.034).结论 PVP可快速缓解OVCF患者的疼痛并改善其生活质量,中-远期疗效主要与其年龄及基础病变程度相关.

Influencing factors of long-mid term efficacy following percutaneous vertebroplastv in patients with osteoporosis

Objective To determine the therapeutic efficacy and the influencing factors for the long/middle-term outcomes of percutaneous vertebroplasty (PVP) in the treatment of painful osteoporotic vertebral compression fractures (OVCFs).Methods This prospective study recruited a total of 131 consecutive OVCF patients treated with PVP at a single institution from March 2005 to December 2009.There were 106 females and 25 males.Pre- and postoperative evaluations included a visual analog scale (VAS) for pain,the Roland-Morris disability questionnaire (RDQ) scores and patient activity levels.Various factors probably correlated with long-mid term efficacy were also analyzed.Results Both VAS and RDQ scores decreased significantly (P ＜ 0.05 ).And the activity levels showed significant post-therapeutic improvement ( P ＜ 0.01 ) ; Univariate and multivariate analysis showed that the influencing factors for the long/middle term efficacy were age,number of OVCF(s) per time,activity level after discharge and newly occurring OVCF (Z =- 2.03,- 2.68,5.38 and - 1.73 ; P =0.043,0.007,0.001 and 0.034 respectively).Conclusion PVP is an efficient pain-relieving procedure.The long/middle-term efficacy after PVP is mostly correlated with both the patient age and the natural course of underlying conditions.