可溶性CXC趋化因子配体16水平与老年男性急性冠状动脉综合征严重程度的相关性

目的 探讨不同类型冠心病患者血中可溶性CXC趋化因子配体16(CXCL16)的水平,以及与冠心病严重程度的关系.方法 选择老年男性共204名,年龄60～92岁,分为对照组(n=40)、稳定型心绞痛组(SAP)(n =80)和急性冠脉综合征组(ACS)(n =84),检测血清CXCL16、生化指标等.结果与对照组(1.87 mg/L)和SAP(2.01 mg/L)患者相比较,ASC患者血清可溶性CXCL16水平(2.35mg/L)显著增高(P =0.001,0.026);CXCL16与年龄(r=0.152,P=0.038)、高敏C反应蛋白(hsCRP,r =0.270,P＜0.001)呈显著相关;将CXCL16水平四分位间距分为Q1～ Q4组,经年龄和hs-CRP校正后,CXCL16水平越高组中ACS的患病风险越大,Q4组(2.270～8.432 mg/L)的OR(95％CI)为7.91(2.41～21.54),而SAP的患病风险无显著性增加,Q4组的OR(95％ CI)为1.72(0.90～3.18).结论老年男性ACS患者血清CXCL16水平较对照组和SAP患者升高,CXCL16水平与老年男性急性冠脉综合征严重程度相关.

Correlation of elevated serum CXCL16 and severity of acute coronary syndromes in male elders

Objective To examine the level of circulating soluble CXC-chemoline ligand 16 (CXCL16)in different types of coronary artery disease and its association with severity of disease.Methods A total of 204 male elders,aged 60-92 years old,were recruited and divided into control group(n =40),stable angina pectoris group(SAP,n =80)and acute coronary syndrome group(ACS,n =84).enzymelinked immunosorbent assay(ELISA)was used to examine the concentration of serum soluble CXCL16.Results As compared with the control(1.87 mg/L)and SAP groups(2.01 mg/L),CXCL16 level was significantly increased in ACS group(2.35 mg/L)P =(0.001,0.026).Correlation analysis showed that CXCL16 was associated with age(r =0.152,P =0.038)and C-reactive protein(CRP)(r =0.270,P ＜0.001).When categorizing CXCL16 into quartiles,logistic analysis adjusted for age and CRP showed that the higher CXCL16 concentrations significantly increased the risk of ACS but not SAP.The odds ratio of group Ⅳ OR(95％ CI)were 7.91(2.41-21.54)versus group Ⅰ as reference in ACS.Conclusion The elevated level of circulating soluble CXCL16 is associated with severity of disease in male elder ACS patients.