| 芪苈强心胶囊对慢性心力衰竭大鼠心脏功能及血浆血管加压素的影响 |
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| 引用本文： | 邬真力,许顶立,林昇,叶桃春,黄鹏,白书昌.芪苈强心胶囊对慢性心力衰竭大鼠心脏功能及血浆血管加压素的影响[J].疑难病杂志,2011,10(2):120-122. |
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| 作者姓名： | 邬真力 许顶立 林昇 叶桃春 黄鹏 白书昌 |
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| 作者单位： | 1. 内蒙古自治区医院心内科,呼和浩特,010017
2. 南方医科大学南方医院心内科,广州,510515 |
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| 基金项目： | ,国家重点基础研究发展计划(国家973计划)资助项目, |
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| 摘 要： | 目的探讨芪苈强心胶囊对慢性心力衰竭(CHF)大鼠心脏功能及血浆血管加压素(AVP)的影响。方法 SD大鼠结扎冠脉前降支,建立CHF大鼠模型,将大鼠随机分为慢性心力衰竭组(C组),芪苈强心高、中、低剂量治疗组(Q1、Q2、Q3组)和呋塞米治疗组(F组),另设假手术组(S组)。药物灌胃6周后检测大鼠超声心动图和血流动力学指标,放射免疫法测定血浆AVP浓度。结果与S组比较,C组大鼠心脏功能显著减退,血浆AVP浓度显著升高(P<0.01)。经过芪苈强心胶囊治疗后,Q1、Q2、Q3组大鼠心脏功能、血流动力学指标均有显著改善,血浆AVP浓度显著降低(P<0.05);F组大鼠心脏功能及血流动力学指标均无显著改善,而血浆AVP浓度显著升高(P<0.05)。结论芪苈强心胶囊可以改善CHF大鼠的心脏功能,降低血浆AVP浓度。
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| 关 键 词： | 血管加压素 心力衰竭 慢性 芪苈强心胶囊 大鼠 |
The effects of Qiliqiangxin capsule on cardiac function and the plasma arginine vasopressin of rats with chronic heart failure |
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| WU Zhen-li,XU Ding-li,LIN Sheng,et al..The effects of Qiliqiangxin capsule on cardiac function and the plasma arginine vasopressin of rats with chronic heart failure[J].Journal of Difficult and Complicated Cases,2011,10(2):120-122. |
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| Authors: | WU Zhen-li XU Ding-li LIN Sheng |
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| Institution: | WU Zhen-li,XU Ding-li,LIN Sheng,et al.* Department of Cardiology,Inner Mongolia Hospital,Hohhot 010017,China |
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| Abstract: | Objective To investigate the effects of Qiliqiangxin capsule on the plasma arginine vasopressin(AVP) of rats with chronic heart failure(CHF).Methods The rats model of CHF was established by ligating the left anterior ascending artery,and then were randomly divided into different doses of Qiliqiangxin capsule treated groups(Q1,Q2 and Q3 group),furosemide treatment group(F group),CHF group(C group) and sham group(S group).Cardiac function of rats were detected at the end of 6th week with echocardiogram and he... |
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| Keywords: | Arginine vasopressin Heart failure chronic Qiliqiangxin capsule Rats |
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