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| 运动训练对急性心肌梗死后心室重构及心肌细胞凋亡的影响 | |
| 引用本文： | 郑昆,杨原,薄海.运动训练对急性心肌梗死后心室重构及心肌细胞凋亡的影响[J].现代中西医结合杂志,2011,20(1):16-19. |
| 作者姓名： | 郑昆 杨原 薄海 |
| 作者单位： | 1. 武警郑州指挥学院门诊部,河南,郑州,451450 2. 武警河南省总队医院,河南,郑州,450001 3. 武警医学院,天津,300162 |
| 基金项目： | 武警总医院科研基金资助项目 |
| 摘 要： | 目的观察急性心肌梗死(AMI)后早期运动训练对左心室重构、泵功能及心肌细胞凋亡的影响及可能机制。方法 30只SD大鼠随机分为假手术组(Sham组)、心梗对照组(AMI-Sed组)和心梗+运动训练组(AMI-Ex组)。AMI模型制作成功后,AMI-Ex组进行8周跑台训练。AMI后9周,进行心脏组织病理学观察,测量心脏指数及Caspase-3和Caspase-9活性,左心室导管法测量血流动力学参数,流式细胞法检测细胞凋亡指数,Western-blotting法检测细胞色素C的释放。结果 AMI-Ex组与AMI-Sed组比较,右室心脏质量指数、肺含水率、左心室压力负荷最大值、心肌细胞凋亡率、Caspase-3和Caspase-9活化水平及细胞色素C释放显著降低。左心室压峰值和左心室压力变化速度正负最大值显著升高。结论 AMI后早期运动训练可以抑制左心室重构以及泵功能障碍,其机制可能与抑制线粒体凋亡通路从而降低非梗死区心肌细胞凋亡率有关。 |
| 关 键 词： | 心肌梗死 心室重塑 运动 细胞凋亡 线粒体 |
Effects of exercise training on ventricular remolding and myocardial apoptosis after myocardial infarction |
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| Zheng Kung,Yang Yuan,Bo Hai.Effects of exercise training on ventricular remolding and myocardial apoptosis after myocardial infarction[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2011,20(1):16-19. | |
| Authors: | Zheng Kung Yang Yuan Bo Hai |
| Institution: | Zheng Kung1,Yang Yuan2,Bo Hai3(1.Zhengzhou Command Academy of Chinese People's Armed Police Force,Zhengzhou 451450,Henan,China,2.Henan Corps Hospital of Chinese People's Armed Police Forces,Zhengzhou 450001,3.Chinese People's Armed Police Force Medical College,Tianjin 300162,China) |
| Abstract: | Objective It is to observe the effect of early exercise training following acute myocardial infarction(AMI) on ventricular remodeling,pump function and myocardial cell apoptosis,and to explore its possible mechanism.Methods Thirty Sprague-Dawley rats were randomly divided into three groups: Sham group,AMI-Sed group and AMI-Ex group.Eight weeks' exercise training was performed on in AMI-Ex group after AMI models were established.Nine weeks after AMI,the heart tissue was collected for morphological and histol... |
| Keywords: | myocardial infarction ventricular remodeling exercise cell apoptosis mitochondria |
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